2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE (glycidyltrimethylammonium chloride)
Official label name (INCI name, EU glossary of cosmetic ingredient names), No 154
- Prohibited in cosmetics (Annex II)
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE (glycidyltrimethylammonium chloride): Prohibited in cosmetics (Annex II, entry 1473), under Regulation (EC) No 1223/2009.
In plain words
What the rules say
It is prohibited to use it in a cosmetic product sold in the European Union, whatever the dose. If it appears on the ingredient list of a recent product, this needs checking: the record may be old or wrong, or the product intended for another market.
Hazard and risk
The CLP Regulation classifies this substance as carcinogenic, category 1B (presumed effect, established mainly from animal studies), mutagenic (may damage DNA), category 2 (suspected effect, without enough evidence for a higher category) and toxic for reproduction, category 2 (suspected effect, without enough evidence for a higher category).
This classification describes what the substance can cause (a hazard), not what happens when using a product (a risk): the risk depends on the dose, the form and the route of exposure (skin, inhalation, ingestion).
Already prohibited in cosmetics (Annex II).
The text of the annexes
Prohibited in cosmetics
CosIng links the name 2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE to this Annex II entry.
- Entry
- Annex II, No 1473
- Substance
- 2,3-Epoxypropyltrimethylammonium chloride; glycidyl trimethylammonium chloride
- CAS
- 3033-77-0
- EC
- 221-221-0
- CMR
- Carcinogenic Cat. 1B(),Mutagenic Cat. 2(),Reprotoxic Cat. 2()
Dates in the act (1)
- Entry into force on 12 June 2019
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Identity
- CosIng identifier
- 95296
- CAS (according to CosIng)
- 3033-77-0
- EC (according to CosIng)
- 221-221-0
- Wikidata
- Q2939557
- PubChem
- 18205
- ECHA InfoCard
- 100.019.293
- InChIKey
- PUVAFTRIIUSGLK-UHFFFAOYSA-M
Classified hazard (CLP Regulation)
A classification describes an intrinsic hazard, not a risk: the risk depends on the dose, the form and the exposure.
2,3-epoxypropyltrimethylammonium chloride … %; glycidyl trimethylammonium chloride … %
CMR Carc. 1B ; Muta. 2 ; Repr. 2
- Hazard classes
- Carc. 1B Muta. 2
Repr. 2
Acute Tox. 4 * Acute Tox. 4 *
STOT RE 2 *
Eye Dam. 1
Skin Sens. 1
Aquatic Chronic 3 - Hazard statements
- H350 H341 H361f*** H312 H302 H373** H318 H317 H412
- CLP notes
- B
Already prohibited in cosmetics (Annex II).
Elsewhere in the world
Information on other jurisdictions. What is covered, and what is not yet.
United Kingdom (Great Britain)
- Prohibited in cosmetics (Annex II)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.