2-CHLORO-P-PHENYLENEDIAMINE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 205
- Prohibited in hair dyes (Annex II)
2-CHLORO-P-PHENYLENEDIAMINE: Prohibited in hair dyes (Annex II, entry 1384), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No harmonised classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
In plain words
What it is used for
Functions declared by manufacturers:
Hair dyeing: colours hair.
Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.
What the rules say
Prohibited as a substance in hair and eyelash dye products. This entry does not cover other uses, which may fall under another annex.
CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.
Origin and odour
No natural occurrence recorded in Wikidata (LOTUS database); this does not prove that the ingredient is synthetic.
Basis: one CosIng CAS, with no natural occurrence recorded in this database.
Wikidata: names of substances in six languages and taxa in which they occur (largely from the LOTUS database), retrieved 23 October 2026.
Present in 0.0% of recorded cosmetics (0 out of 22 328).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
The text of the annexes
Prohibited in hair dyes
CosIng links the name 2-CHLORO-P-PHENYLENEDIAMINE to this entry. The cases of prohibition are explained above, in “In plain words”; the official title is given below.
- Entry
- Annex II, No 1384
- Substance
- 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products, including eyebrow dye products, and eyelash dye products
- CAS
- 615-66-7; 61702-44-1 (sulfate); 615-46-3 (dihydrochloride)
- EC
- 210-441-2; 262-915-3; 210-427-6
Dates in the act (3)
- Entry into force on 22 May 2019
- Placing on the market from 22 November 2019
From 22 November 2019 hair dye products, including eyebrow dye products, and eyelash dye products containing those substances shall not be placed on the Union market
- Making available from 22 February 2020
From 22 February 2020 hair dye products, including eyebrow dye products, and eyelash dye products containing those substances shall not be made available on the Union market
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Regulation (EC) No 1223/2009, Annex II, entry 1384. CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EU) 2019/681, adopted on 30 April 2019.
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex II, entry 1384: introduced or replaced by Regulation (EU) 2019/681
Annex II, entry 1384: a new product that does not comply can no longer be placed on the market
Annex II, entry 1384: a product that does not comply can no longer be sold, even from stock
Identity
- CosIng identifier
- 31495
- CAS (according to CosIng)
- 615-66-7
- EC (according to CosIng)
- 210-441-2
- Declared functions
- Hair dyeing
- Wikidata
- Q27146147
- PubChem
- 11998
- ECHA InfoCard
- 100.009.493
- InChIKey
- MGLZGLAFFOMWPB-UHFFFAOYSA-N
CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Wikidata, items with a CosIng identifier (P3073), retrieved 22 October 2026.
Wikidata, PubChem and ECHA links are published only when verified: same CosIng identifier, a single item, matching CAS number.
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Prohibited in hair dyes | not cited |
| United Kingdom | Prohibited in hair dyes | not cited |
| Switzerland | EU Regulation applies | not cited |
| United States (federal) | No federal rule recorded | not cited |
| Canada | No entry in the lists recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | No entry in the lists recorded | not cited |
| China | Prohibited differs from the EU | not cited |
| Australia | No entry in the lists recorded | not cited |
| ASEAN | Prohibited in certain cases (see the rule) | not cited |
| Taiwan | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Prohibited in hair dyes (Annex II)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
China
- Prohibited: 2-氯对苯二胺，2-氯对苯二胺硫酸盐 (2-chlorobenzene-1,4-diamine （2-Chloro-p-Phenylenediamine） （CAS No. 615-66-7） and its sulfate salts （CAS No. 61702-44-1）)
表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 1263, page 附件2 (.doc) table row 1263 ; TID reprint p.47.
China, NMPA catalogues of prohibited cosmetic ingredients (2021 No. 74, revised up to 2026), retrieved 22 October 2026.
Source: 国家药品监督管理局 (NMPA); plant catalogue as reprinted by the Trade and Industry Department of Hong Kong; table formatted by the publisher of this site.
ASEAN (South-East Asia)
- Prohibited: 2-chlorobenzene-1,4-diamine (2-Chloro-p-Phenylenediamine), its sulfate and dihydrochloride salts when used as a substance in hair dye products
Annex II (prohibited substances), entry 1384, page 64.
ASEAN Cosmetic Directive, Annexes II, III, IV, VI and VII (version 2026-1 of 22 June 2026, Annex VII 2025-2), retrieved 24 October 2026.
Source: ASEAN Cosmetic Documents, Annexes of the ASEAN Cosmetic Directive, as published by the Health Sciences Authority (HSA, Singapore); table extracted and formatted by the publisher of this site, with no endorsement by HSA or ASEAN.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.