2-HYDROXYETHYL PICRAMIC ACID
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 219
- Allowed with restrictions (Annex III)
2-HYDROXYETHYL PICRAMIC ACID: Allowed with restrictions, with limits depending on the product type (Annex III, entry 222), under Regulation (EC) No 1223/2009. Good to know: classified toxic for reproduction (category 2). Annexes of the Regulation consulted on 21 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.
Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment. Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: reproductive toxicity, category 2 (Repr. 2), a hazard to fertility. The European Union nevertheless allows it under the conditions of its annex, after an opinion of its Scientific Committee on Consumer Safety (SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients.).
For a question about your own situation, ask your doctor, midwife or pharmacist.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No official classification as hazardous to the aquatic environment and no assessment as an endocrine disruptor for the environment.
Read on the label
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance. Annex III, entry 222, requires this to be printed on the pack: “(a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: —”.
In plain words
What it is used for
Functions declared by manufacturers:
Hair dyeing: colours hair.
What the rules say
Allowed, with restrictions: Annex III sets a maximum concentration, the product types allowed and a warning to be printed on the packaging. Ingredient lists do not give quantities, so the concentration cannot be checked on the label; the warning can.
Hazard and risk
The CLP Regulation classifies this substance as toxic for reproduction, category 2 (suspected effect, without enough evidence for a higher category).
This classification describes what the substance can cause (a hazard), not what happens when using a product (a risk): the risk depends on the dose, the form and the route of exposure (skin, inhalation, ingestion).
Classified as a category 2 CMRCarcinogenic, mutagenic (damages DNA) or toxic for reproduction. and allowed under the conditions of Annex III, after an SCCS assessment.
The text of the annexes
Allowed with restrictions
| Product type | Maximum concentration | Other conditions | Warning to print |
|---|---|---|---|
| (a) Hair dye substance in oxidative hair day products | not set | and | To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in |
| (b) Hair dye substance in non-oxidative hair day products | 2.0% | : - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/kg - Kep in nitrite-free containers | not set |
- Entry
- Annex III, No 222
- Substance
- 1-Hydroxy-2-beta-hydroxyethylamino-4,6-dinitrobenzene
- Glossary names
- 2-HYDROXYETHYL PICRAMIC ACID
- CAS
- 99610-72-7
- EC
- 412-520-9
Dates in the act (3)
- Entry into force on 15 May 2013
- Application from 11 July 2013
It shall apply from 11 July 2013.
- Entry into force on 11 July 2013
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex III, entry 222: introduced or replaced by Regulation (EU) n° 344/2013
Annex III, entry 222: applies from this date
CLP classification “Repr. 2” applicable at the latest from this date (Regulation (EU) 2018/669)
Identity
- CosIng identifier
- 31498
- CAS (according to CosIng)
- 99610-72-7
- EC (according to CosIng)
- 412-520-9
- Declared functions
- Hair dyeing
- Wikidata
- Q27282517
- PubChem
- 5463814
- ECHAEuropean Chemicals Agency. InfoCard
- 100.101.184
- InChIKey
- OABRBVCUJIJMOB-UHFFFAOYSA-N
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
2-(2-hydroxy-3,5-dinitroanilino)ethanol
Reproductive toxicity, category 2 (Repr. 2)
- Hazard classes
- Flammable solid, category 2 (Flam. Sol. 2)
Reproductive toxicity, category 2 (Repr. 2)
Acute toxicity, category 4 (Acute Tox. 4) - Hazard statements
- H228 H361f *** H302
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Allowed with restrictions | 2% |
| United Kingdom | Allowed with restrictions | 2% |
| Switzerland | EU Regulation applies | 2% |
| United States (federal) | No federal rule recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | Prohibited differs from the EU | 1.5 to 2% |
| China | No entry in the lists recorded | not cited |
| Australia | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Prohibited: 1-하이드록시-2-베타-하이드록시에칠아미노-4,6-디니트로벤젠 및 그 염류(예 : 2-하이드록시에칠피크라믹애씨드) (2-HYDROXYETHYL PICRAMIC ACID)
별표 1 (prohibited substances), entry 1018, page 51.
Conditions, source text, in Korean
화학물질명: 2-하이드록시에칠피크라믹애씨드 (CAS No. 99610-72-7) | ※ 유의사항 2: 1) 표시는 [별표 2] 염모제 성분에서 정한 기준에 적합한 경우는 제외한다.
- Restricted: 2-하이드록시에칠피크라믹애씨드 (2-HYDROXYETHYL PICRAMIC ACID)
별표 2, 염모제 성분 (hair colorants), entry 69, page 24-25. Limit: ·산화염모제에 1.5% ·비산화염모제에 2.0%.
Conditions, source text, in Korean
비고: 기타제품에는 사용금지
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.