4,4'-ISOPROPYLIDENEDIPHENOL

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

• Pregnancy and breastfeeding

  Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).

  Prohibition or serious classification Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: reproductive toxicity, category 1B (Repr. 1B), a hazard to fertility.

  Prohibition or serious classification ECHAEuropean Chemicals Agency. has included it in the Candidate List as an endocrine disruptor for human health.

  For a question about your own situation, ask your doctor, midwife or pharmacist.

• Babies and children

  Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.

• Skin, eyes and allergies

  Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.

  Worth watching Classified under the CLP Regulation: serious eye damage, category 1 (Eye Dam. 1); skin sensitisation, category 1 (Skin Sens. 1).

• Environment

  Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).

  Worth watching Classified under the CLP Regulation: hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1); hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1).

  Prohibition or serious classification ECHA has included it in the Candidate List as an endocrine disruptor for the environment.

• Read on the label

  The Cosmetics Regulation requires no warning to be printed for this ingredient.

Prohibited in cosmetics

CosIng links the name 4,4'-ISOPROPYLIDENEDIPHENOL to this Annex II entry.

Entry

Annex II, No 1176

Substance

Bisphenol A (4,4'-Isopropylidenediphenol)

CAS

80-05-7

EC

201-245-8

Identity

CosIng identifier

84605

CAS (according to CosIng)

80-05-7

EC (according to CosIng)

201-245-8

4,4'-isopropylidenediphenol; bisphenol A

Reproductive toxicity, category 1B (Repr. 1B)

Hazard classes

Reproductive toxicity, category 1B (Repr. 1B)
Specific target organ toxicity, single exposure, category 3 (STOT SE 3)
Serious eye damage, category 1 (Eye Dam. 1)
Skin sensitisation, category 1 (Skin Sens. 1)
Hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1)
Hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1)

Hazard statements

H360F H335 H318 H317 H400 H410

• Identified as an endocrine disruptor at EU level

Recorded evaluations

• Candidate list, REACH (health and environment)

United Kingdom (Great Britain)

• Prohibited in cosmetics (Annex II)

Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

Canada

• Prohibited: 4,4'-(propane-2,2-diyl)diphénol (4,4'-Isopropylidenediphenol)

  Hotlist, prohibited ingredients. Synonyms and related compounds: Bisphenol A

South Korea

• Prohibited: 비스페놀 A(4,4’-이소프로필리덴디페놀)

  별표 1 (prohibited substances), entry 417, page 22.

China

• Prohibited: 双酚 A （二酚基丙烷） (Bisphenol A （4,4’-Isopropylidenediphenol） （CAS No. 80-05-7）)

  表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 358, page 附件2 (.doc) table row 358 ; TID reprint p.15.

ASEAN (South-East Asia)

• Prohibited: Bisphenol A (4,4'-Isopropylidenediphenol)

  Annex II (prohibited substances), entry 1176, page 52.

Brazil

• Prohibited: Bisfenol A

  RDC 529/2021, Anexo (prohibited substances), entry 1176, page 40.

  Conditions, source text, in Portuguese

  N° UE: 1176

1 products reported with this ingredient, with no discontinuation reported in the source. Reports may concern earlier formulas, including chemicals since removed. This is company reporting, not a product test or a measure of quantity. See the products (in French). California and EU rules differ.

2 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).