CompoAtlas

4-AMINO-2-NITRODIPHENYLAMINE-2'-CARBOXYLIC ACID

Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 314

4-AMINO-2-NITRODIPHENYLAMINE-2'-CARBOXYLIC ACID: Prohibited in hair dyes (Annex II, entry 1644), under Regulation (EC) No 1223/2009. Good to know: classified as a sensitiser (skin allergy); hazardous to the aquatic environment. Annexes of the Regulation consulted on 23 October 2026.

Who it concerns

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  • Pregnancy and breastfeeding

    No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.

  • Babies and children

    The Cosmetics Regulation sets no age-related condition for this ingredient.

  • Skin, eyes and allergies

    Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.

    Worth watching Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: serious eye damage, category 1 (Eye Dam. 1); skin sensitisation, category 1 (Skin Sens. 1).

  • Environment

    For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

    For information Classified under the CLP Regulation: hazardous to the aquatic environment, long term, category 3 (Aquatic Chronic 3).

  • Read on the label

    The Cosmetics Regulation requires no warning to be printed for this ingredient.

In plain words

What it is used for

Functions declared by manufacturers:

Hair dyeing: colours hair.

Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.

Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.

What the rules say

Prohibited as a substance in hair and eyelash dye products. This entry does not cover other uses, which may fall under another annex.

CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.

Origin and odour

No natural occurrence recorded in Wikidata (LOTUS database); this does not prove that the ingredient is synthetic.

Basis: one CosIng CAS, with no natural occurrence recorded in this database.

Present in 0.0% of recorded cosmetics (0 out of 22 298).

Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.

Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.

The text of the annexes

Prohibited in hair dyes

CosIng links the name 4-AMINO-2-NITRODIPHENYLAMINE-2'-CARBOXYLIC ACID to this entry. The cases of prohibition are explained above, in “In plain words”; the official title is given below.

Entry
Annex II, No 1644
Substance
2-[(4-Amino-2-nitrophenyl)-amino]-benzoic acid when used as a substance in hair and eyelash dye products
CAS
117907-43-4
EC
411-260-3
Dates in the act (5)
  • Entry into force on 3 December 2020
  • Condition applicable from 3 June 2021
    As from 3 June 2021: 0,5 % Methanesulfonates impurities, in particular ethyl methanesulfonate shall not be present
  • Placing on the market from 3 June 2021
    As from 3 June 2021: 25 %’ (*1) From 3 September 2021 hair and eyelash dye products containing those substances shall not be placed on the Union market
  • Condition applicable from 3 December 2021
    As from 3 December 2021, to be printed on the label: The mixing ratio
  • Making available from 3 June 2022
    From 3 June 2022 hair and eyelash dye products containing those substances shall not be made available on the Union market

Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.

Regulation (EC) No 1223/2009, Annex II, entry 1644. CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.

Entry from Regulation (EU) 2020/1683, adopted on 12 November 2020.

SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: Opinion concerning 4-Amino-2-nitrodiphenylamine-2'-carboxylic acid.

What has changed, and what will change

Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.

  1. CLP classification “Eye Dam. 1” applicable at the latest from this date (Regulation (EU) 2018/669)

  2. Annex II, entry 1644: introduced or replaced by Regulation (EU) 2020/1683

  3. Annex II, entry 1644: a new product that does not comply can no longer be placed on the market

  4. Annex II, entry 1644: a product that does not comply can no longer be sold, even from stock

Identity

CosIng identifier
31523
CAS (according to CosIng)
117907-43-4
EC (according to CosIng)
411-260-3
Declared functions
Hair dyeing
Wikidata
Q27279379
PubChem
9860314
ECHA InfoCard
100.101.073
InChIKey
YESOPQNVGIQNEV-UHFFFAOYSA-N

CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.

Wikidata, items with a CosIng identifier (P3073), retrieved 22 October 2026.

Wikidata, PubChem and ECHAEuropean Chemicals Agency. links are published only when verified: same CosIng identifier, a single item, matching CAS number.

Classified hazard (CLP Regulation)

The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.

2-((4-amino-2-nitrophenyl)amino)benzoic acid

Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification

Hazard classes
Serious eye damage, category 1 (Eye Dam. 1)
Skin sensitisation, category 1 (Skin Sens. 1)
Hazardous to the aquatic environment, long term, category 3 (Aquatic Chronic 3)
Hazard statements
H318 H317 H412

Annex VI, entry 607-382-00-3, linked by CAS 117907-43-4. Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.

Entry introduced or replaced by Regulation (EU) 2018/669, applicable at the latest from 1 December 2019.

Elsewhere in the world

Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.

Comparison between countries

Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.

Comparison between countries: 4-AMINO-2-NITRODIPHENYLAMINE-2'-CARBOXYLIC ACID
CountryRuleMaximum concentration cited
European UnionProhibited in hair dyesnot cited
United KingdomProhibited in hair dyesnot cited
SwitzerlandEU Regulation appliesnot cited
United States (federal)No federal rule recordednot cited
CanadaNo entry in the lists recordednot cited
JapanNo entry in the lists recordednot cited
South KoreaNo entry in the lists recordednot cited
ChinaNot on the prohibited lists recorded (lists of allowed substances are not recorded)not cited
AustraliaNo entry in the lists recordednot cited
ASEANProhibited in certain cases (see the rule)not cited
TaiwanNo entry in the lists recordednot cited
BrazilNo entry in the lists recordednot cited

United Kingdom (Great Britain)

  • Prohibited in hair dyes (Annex II)

Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.

Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.

Contains public sector information licensed under the Open Government Licence v3.0.

Northern Ireland applies EU law.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.

The eCFR is not an official legal edition of the Code of Federal Regulations.

ASEAN (South-East Asia)

  • Prohibited: 2-[(4-Amino-2-nitrophenyl)-amino]-benzoic acid when used as a substance in hair and eyelash dye products

    Annex II (prohibited substances), entry 1644, page 93.

ASEAN Cosmetic Directive, Annexes II, III, IV, VI and VII (version 2026-1 of 22 June 2026, Annex VII 2025-2), retrieved 24 October 2026.

Source: ASEAN Cosmetic Documents, Annexes of the ASEAN Cosmetic Directive, as published by the Health Sciences Authority (HSA, Singapore); table extracted and formatted by the publisher of this site, with no endorsement by HSA or ASEAN.

Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.

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