4-NITROGUAIACOL

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

• Pregnancy and breastfeeding

  No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.

• Babies and children

  The Cosmetics Regulation sets no age-related condition for this ingredient.

• Skin, eyes and allergies

  No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.

• Environment

  No official classification as hazardous to the aquatic environment and no assessment as an endocrine disruptor for the environment.

• Read on the label

  The Cosmetics Regulation requires no warning to be printed for this ingredient.

Prohibited in hair dyes

CosIng links the name 4-NITROGUAIACOL to this entry. The cases of prohibition are explained above, in “In plain words”; the official title is given below.

Entry

Annex II, No 1251

Substance

2-Methoxy-4-nitrophenol (4-Nitroguaiacol) and its salts, when used as a substance in hair dye products

CAS

3251-56-7

EC

221-839-0

Identity

CosIng identifier

31530

CAS (according to CosIng)

3251-56-7

EC (according to CosIng)

221-839-0

Declared functions

Hair dyeing

United Kingdom (Great Britain)

• Prohibited in hair dyes (Annex II)

Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

South Korea

• Prohibited: 2-메톡시-4-니트로페놀(4-니트로구아이아콜) 및 그 염류 (4-NITROGUAIACOL)

  별표 1 (prohibited substances), entry 281, page 14.

  Conditions, source text, in Korean

  화학물질명: 2-메톡시-4-니트로페놀(4-니트로구아이아콜) (CAS No. 3251-56-7) | 화학물질명: 2-메톡시-4-니트로페놀(4-니트로구아이아콜) 포타슘 솔트 (CAS No. 304675-72-7)

China

• Prohibited: 4-硝基-2-甲氧基苯酚（4-硝基愈创木酚）及其盐类 (2-Methoxy-4-nitrophenol （4-Nitroguaiacol） （CAS No. 3251-56-7） and its salts)

  表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 115, page 附件2 (.doc) table row 115 ; TID reprint p.6.

Brazil

• Prohibited: 2-metoxi-4-nitrofenol e seus sais, quando usado como substância que entra na composição de corantes capilares

  RDC 529/2021, Anexo (prohibited substances), entry 1251, page 42.

  Conditions, source text, in Portuguese

  N° UE: 1251