BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 3458
- UV filter allowed under conditions (Annex VI)
BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE: UV filter allowed under conditions, maximum 10% in the ready-for-use preparation (Annex VI, entry 33), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No harmonised classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
In plain words
What the rules say
An ingredient can be used as a UV filter only if it appears on the list of Annex VI. BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE is on it with a maximum concentration.
CosIng, Annex VI of Regulation (EC) No 1223/2009 (allowed UV filters), retrieved 23 October 2026, source updated 13 October 2026.
Origin and odour
Present in 0.0% of recorded cosmetics (0 out of 22 298).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
The text of the annexes
UV filter allowed under conditions
- Maximum concentration
- 10% (In case of combined use of Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine and Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine (nano), the sum shall not exceed 10%).
- Entry
- Annex VI, No 33
- Substance
- 1,1'-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone
- Glossary names
- BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE
- CAS
- 919803-06-8
- EC
- 485-100-6
Dates in the act (5)
- Entry into force on 1 December 2022
- Placing on the market from 1 July 2023
From 1 July 2023 cosmetic products containing that substance and not complying with the restrictions shall not be placed on the Union market
- Making available from 1 January 2024
From 1 January 2024 cosmetic products containing that substance and not complying with the restrictions shall not be made available on the Union market
- Placing on the market from 1 January 2025
From 1 January 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market
- Making available from 1 July 2025
From 1 July 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Regulation (EC) No 1223/2009, Annex VI, entry 33. CosIng, Annex VI of Regulation (EC) No 1223/2009 (allowed UV filters), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EU) 2022/2195, adopted on 10 November 2022.
SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: OPINIONON2-(4-(2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl)-piperazine-1-carbonyl)-phenyl)-(4-diethylamino-2-hydroxyphenyl)-methanone(HAA299) as UV filter in sunscreen products; HAA299 (nano).
UV filter allowed under conditions
CosIngThe European Commission's database of cosmetic ingredients. cites the name BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE in this entry, whose regulated name is “BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE (NANO)”: the title below says which form or use it covers.
- Maximum concentration
- 10% (In case of combined use of Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine and Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine (nano), the sum shall not exceed 10%).
- Other conditions
- Only nanomaterials having the following characteristics are allowed: — Purity ≥ 97 % —Median particle size D50 (50 % of the number below this diameter): ≥ 50 nm of number size distribution. Not to be used in applications that may lead to exposure of the end user’s lungs by inhalation.
- Entry
- Annex VI, No 34
- Substance
- 1,1'-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone
- Glossary names
- BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE (NANO)
- CAS
- 919803-06-8
- EC
- 485-100-6
Dates in the act (5)
- Entry into force on 1 December 2022
- Placing on the market from 1 July 2023
From 1 July 2023 cosmetic products containing that substance and not complying with the restrictions shall not be placed on the Union market
- Making available from 1 January 2024
From 1 January 2024 cosmetic products containing that substance and not complying with the restrictions shall not be made available on the Union market
- Placing on the market from 1 January 2025
From 1 January 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market
- Making available from 1 July 2025
From 1 July 2025 cosmetic products containing that substance and not complying with the conditions shall not be made available on the Union market
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Regulation (EC) No 1223/2009, Annex VI, entry 34. CosIng, Annex VI of Regulation (EC) No 1223/2009 (allowed UV filters), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EU) 2022/2195, adopted on 10 November 2022.
SCCS opinions cited: OPINIONON2-(4-(2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl)-piperazine-1-carbonyl)-phenyl)-(4-diethylamino-2-hydroxyphenyl)-methanone(HAA299) as UV filter in sunscreen products; HAA299 (nano).
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex VI, entry 33: introduced or replaced by Regulation (EU) 2022/2195
Annex VI, entry 33: a new product that does not comply can no longer be placed on the market
Annex VI, entry 33: a product that does not comply can no longer be sold, even from stock
Annex VI, entry 33: a new product that does not comply can no longer be placed on the market
Annex VI, entry 33: a product that does not comply can no longer be sold, even from stock
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | UV filter allowed under conditions | 10% |
| United Kingdom | UV filter allowed under conditions | 10% |
| Switzerland | EU Regulation applies | 10% |
| United States (federal) | No federal rule recorded | not cited |
| Canada | No entry in the lists recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | No entry in the lists recorded | not cited |
| China | Not on the prohibited lists recorded (lists of allowed substances are not recorded) | not cited |
| Australia | No entry in the lists recorded | not cited |
| ASEAN | No entry in the lists recorded | not cited |
| Taiwan | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- UV filter allowed under conditions (Annex VI)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.