CHOLINE CHLORIDE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 6272
- Prohibited in cosmetics (Annex II)
CHOLINE CHLORIDE: Prohibited in cosmetics (Annex II, entry 168), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 21 October 2026.
Who it concerns
This ingredient is prohibited in cosmetics in the European Union: what follows describes its hazards, not a permitted use.
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No official classification as hazardous to the aquatic environment and no assessment as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
In plain words
What it is used for
Functions declared by manufacturers:
Humectant: holds and retains moisture.
Skin conditioning: maintains the skin in good condition.
What the rules say
It is prohibited to use it in a cosmetic product sold in the European Union, whatever the dose. If it appears on the ingredient list of a recent product, this needs checking: the record may be old or wrong, or the product intended for another market.
The text of the annexes
Prohibited in cosmetics
CosIng links the name CHOLINE CHLORIDE to this Annex II entry.
- Entry
- Annex II, No 168
- Substance
- Choline salts and their esters e.g. choline chloride (INN)
- CAS
- 67-48-1
- EC
- 200-655-4
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex II, entry 168: introduced or replaced by Regulation (EC) No 1223/2009
Annex II, entry 168: applies from this date
Identity
- CosIng identifier
- 85095
- CAS (according to CosIng)
- 67-48-1
- EC (according to CosIng)
- 200-655-4
- Declared functions
- Humectant, Skin conditioning
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Prohibited in cosmetics | not cited |
| United Kingdom | Prohibited in cosmetics | not cited |
| Switzerland | EU Regulation applies | not cited |
| United States (federal) | No federal rule recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | Prohibited | not cited |
| China | Prohibited | not cited |
| Australia | No entry in the lists recorded | not cited |
| Brazil | Prohibited | not cited |
United Kingdom (Great Britain)
- Prohibited in cosmetics (Annex II)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Prohibited: 콜린염 및 에스텔(예 : 콜린클로라이드) (CHOLINE CHLORIDE)
별표 1 (prohibited substances), entry 718, page 38.
Conditions, source text, in Korean
화학물질명: 콜린클로라이드 (CAS No. 67-48-1)
China
- Prohibited: 胆碱的盐类及它们的酯类,包括氯化胆碱、菲诺贝特胆碱、胆碱水杨 酸盐、胆碱葡萄糖酸盐、胆茶碱、硬脂酸等长链烷烃羧酸胆碱酯; 不包括卵磷脂、甘油磷酸胆碱、氢化溶血卵磷酸酯酰胆碱、氢化卵磷酰 胆碱、卵磷酰胆碱类; 其他相关原料需经安全风险评估方可确定 (Choline salts and their esters, including choline chloride （INN） （CAS No. 67-48-1）, choline fenofibrate （CAS No. 856676-23-8）, choline salicylate （CAS No. 2016-36-6）, choline gluconate （CAS No. 507-30-2）, choline theophylline （CAS No. 4499-40-5）, choline esters of stearic acid and other long alkyl chain carboxylic acids; excluding lecithin （CAS No. 93685-90-6）, glycerophosphocholine （CAS No. 28319-77-9）, hydrogenated lysophosphatidylcholine （CAS No. 9008-30-4）, hydrogenated phosphatidylcholine（CAS No. 97281-48-6）, phosphatidylcholine （CAS No. 8002-43-5）; the usage of other relevant ingredients requires safety assessment)
表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 410, page 附件2 (.doc) table row 410 ; TID reprint p.17.
Brazil
- Prohibited: Ésteres da Colina e da metilcolina e seus sais exceto Lecitina
RDC 529/2021, Anexo (prohibited substances), entry 168, page 7.
Conditions, source text, in Portuguese
N° UE: 168
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.