DI-HEMA TRIMETHYLHEXYL DICARBAMATE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 8645
- Allowed with restrictions (Annex III)
DI-HEMA TRIMETHYLHEXYL DICARBAMATE: Allowed with restrictions (Annex III, entry 314), under Regulation (EC) No 1223/2009. Good to know: classified as a sensitiser (skin allergy). Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.
Worth watching Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: skin sensitisation, category 1B (Skin Sens. 1B).
Environment
No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.
Read on the label
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For information Annex III, entry 314, requires this to be printed on the pack: “For professional use only. Can cause an allergic reaction.”.
Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
In plain words
What it is used for
Functions declared by manufacturers:
Nail sculpting.
Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.
What the rules say
Allowed, with restrictions: Annex III sets the product types allowed and a warning to be printed on the packaging. Ingredient lists do not give quantities, so the concentration cannot be checked on the label; the warning can.
CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Origin and odour
Present in 0.0% of recorded cosmetics (0 out of 22 328).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
The text of the annexes
Allowed with restrictions
- Product type
- Nail products
- Other conditions
- Professional use only
- Warning to print
- For professional use only. Can cause an allergic reaction.
- Entry
- Annex III, No 314
- Substance
- 11,14-Dioxa-2,9-diazaheptadec-16-enoic Acid, 4,4,6,16-tetramethyl-10,15-dioxo, 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester
- Glossary names
- DI-HEMA TRIMETHYLHEXYL DICARBAMATE
- CAS
- 41137-60-4 / 72869-86-4
- EC
- 255-239-5 / 276-957-5
Dates in the act (3)
- Entry into force on 3 December 2020
- Placing on the market from 3 June 2021
From 3 June 2021 products containing that substance and not complying with those conditions shall not be placed on the Union market
- Making available from 3 September 2021
From 3 September 2021 products containing that substance and not complying with those conditions shall not be made available on the Union market
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Regulation (EC) No 1223/2009, Annex III, entry 314. CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EU) 2020/1682, adopted on 12 November 2020.
SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: OPINION ON the safety of cosmetic ingredients HEMA and Di-HEMA Trimethylhexyl Dicarbamate Submission I (Sensitisation only).
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex III, entry 314: introduced or replaced by Regulation (EU) 2020/1682
Annex III, entry 314: a new product that does not comply can no longer be placed on the market
Annex III, entry 314: a product that does not comply can no longer be sold, even from stock
CLP classification “Skin Sens. 1B” applicable at the latest from this date (Regulation (EU) 2024/197)
Identity
- CosIng identifier
- 55729
- CAS (according to CosIng)
- 41137-60-4, 72869-86-4
- EC (according to CosIng)
- 276-957-5
- Declared functions
- Nail sculpting
CosIng cites 2 CAS numbers for this name: it covers several substances.
CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
7,7,9(or 7,9,9)-trimethyl–4,13-dioxo–3,14-dioxa–5,12-diazahexadecane–1,16-diyl bismethacrylate
Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification
- Hazard classes
- Skin sensitisation, category 1B (Skin Sens. 1B)
- Hazard statements
- H317
Annex VI, entry 607-767-00-6, linked by CAS 72869-86-4. Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
Entry introduced or replaced by Regulation (EU) 2024/197, applicable at the latest from 1 September 2025.
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Allowed with restrictions | not cited |
| United Kingdom | Allowed with restrictions | not cited |
| Switzerland | EU Regulation applies | not cited |
| United States (federal) | No federal rule recorded | not cited |
| Canada | No entry in the lists recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | No entry in the lists recorded | not cited |
| China | Not on the prohibited lists recorded (lists of allowed substances are not recorded) | not cited |
| Australia | No entry in the lists recorded | not cited |
| ASEAN | Restricted (conditions or maximum concentration) | not cited |
| Taiwan | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
ASEAN (South-East Asia)
- Restricted (conditions or maximum concentration): 11,14-Dioxa-2,9- diazaheptadec-16-enoic Acid, 4,4,6,16- tetramethyl-10,15- dioxo, 2-[(2-methyl- 1-oxo-2-propenyl) oxy]ethyl ester DI-HEMA TRIMETHYLHEXYL DICARBAMATE
Annex III (restricted substances), entry 329, page 248.
Conditions, source text
Ref column: (314) | Field of application and/or use: Nail Products | Other limitations and requirements: Professional use only | Conditions of use and warning which must be printed on the labels: For professional use only Can cause an allergic reaction
ASEAN Cosmetic Directive, Annexes II, III, IV, VI and VII (version 2026-1 of 22 June 2026, Annex VII 2025-2), retrieved 24 October 2026.
Source: ASEAN Cosmetic Documents, Annexes of the ASEAN Cosmetic Directive, as published by the Health Sciences Authority (HSA, Singapore); table extracted and formatted by the publisher of this site, with no endorsement by HSA or ASEAN.
Recorded cosmetics that contain it
8 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.