DIHYDROXYINDOLE (5,6-dihydroxyindole)

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

• Pregnancy and breastfeeding

  No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.

• Babies and children

  The Cosmetics Regulation sets no age-related condition for this ingredient.

• Skin, eyes and allergies

  For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  For information Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: serious eye damage, category 1 (Eye Dam. 1). This classification describes the pure substance; in a finished product it is far more diluted.

• Environment

  For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  For information Classified under the CLP Regulation: hazardous to the aquatic environment, long term, category 2 (Aquatic Chronic 2).

• Read on the label

  For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  For information Annex III, entry 207, requires this to be printed on the pack: “To be printed on the label: Hair colorants can cause severe allergic reactions.”.

Allowed with restrictions

This entry covers the same substance as DIHYDROXYINDOLE (same CAS number in the CosIng inventory): its conditions apply.

Product type

(a) Hair dye substance in oxidative hair dye products

Other conditions

(a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,5%

Warning to print

To be printed on the label: Hair colorants can cause severe allergic reactions.

Entry

Annex III, No 207

Substance

1H-Indole-5,6-diol

Glossary names

DIHYDROXY-INDOLE

CAS

3131-52-0

EC

412-130-9

Identity

CosIng identifier

33365

CAS (according to CosIng)

3131-52-0

EC (according to CosIng)

412-130-9

Declared functions

Hair dyeing

Wikidata

Q9207472

PubChem

114683

ECHA InfoCard

100.101.149

InChIKey

SGNZYJXNUURYCH-UHFFFAOYSA-N

5,6-dihydroxyindole

Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification

Hazard classes

Acute toxicity, category 4 (Acute Tox. 4)
Serious eye damage, category 1 (Eye Dam. 1)
Hazardous to the aquatic environment, long term, category 2 (Aquatic Chronic 2)

Hazard statements

H302 H318 H411

United Kingdom (Great Britain)

• Allowed with restrictions (Annex III)

Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

ASEAN (South-East Asia)

• Restricted (conditions or maximum concentration): 1H-Indole-5,6-diol Dihydroxyindole

  Annex III (restricted substances), entry 257, page 190. Limit: (b) 0.5%.

  Conditions, source text

  Ref column: (207) | Field of application and/or use: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. | Other limitations and requirements: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5% (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text. | Conditions of use and warning which must be printed on the labels: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Taiwan

• Restricted (conditions or maximum concentration): 1H-Indole-5,6-diol (Dihydroxyindole)

  化粧品成分使用限制表 (restricted substances). Limit: (a)0.5% (b)0.5%.

  Conditions, source text, in Chinese

  產品類型／使用範圍：(a)氧化性染髮產品 (b)非氧化性染髮產品