Compoatlas

HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE

Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 13193

HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE: Prohibited in cosmetics (Annex II, entry 344); allowed with restrictions, maximum 0.5% in the ready-for-use preparation, only in: Hair dye substance in non-oxidative hair dye products (Annex III, entry 293), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 23 October 2026.

Who it concerns

This ingredient is prohibited in cosmetics in the European Union: what follows describes its hazards, not a permitted use.

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  • Pregnancy and breastfeeding

    Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.

  • Babies and children

    Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.

  • Skin, eyes and allergies

    No harmonised classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.

  • Environment

    No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.

  • Read on the label

    For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

    For information Annex III, entry 293, requires this to be printed on the pack: “To be printed on the label: “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, —you have experienced a reaction to a temporary “black henna” tattoo in the past.””.

CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.

In plain words

What it is used for

Functions declared by manufacturers:

Hair dyeing: colours hair.

Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.

Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.

What the rules say

It is prohibited to use it in a cosmetic product sold in the European Union, whatever the dose. If it appears on the ingredient list of a recent product, this needs checking: the record may be old or wrong, or the product intended for another market.

Allowed, with restrictions: Annex III sets a maximum concentration, the product types allowed and a warning to be printed on the packaging. Ingredient lists do not give quantities, so the concentration cannot be checked on the label; the warning can.

CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.

CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.

Origin and odour

No natural occurrence recorded in Wikidata (LOTUS database); this does not prove that the ingredient is synthetic.

Basis: one CosIng CAS, with no natural occurrence recorded in this database.

Present in 0.0% of recorded cosmetics (3 out of 22 508).

Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.

Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.

The text of the annexes

Prohibited in cosmetics

CosIng links the name HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE to this Annex II entry.

Entry
Annex II, No 344
Substance
Morpholine and its salts
CAS
110-91-8
EC
203-815-1

Regulation (EC) No 1223/2009, Annex II, entry 344. CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.

Entry from Regulation (EC) No 1223/2009, adopted on 30 November 2009.

Allowed with restrictions

This entry covers the same substance as HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE (same CAS number in the CosIng inventory): its conditions apply.

Product type
Hair dye substance in non-oxidative hair dye products
Maximum concentration
0.5%
Other conditions
—Do not use with nitrosating agents —Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers
Warning to print
To be printed on the label: “Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, —you have experienced a reaction to a temporary “black henna” tattoo in the past.”
Entry
Annex III, No 293
Substance
1-N-Methylmorpholiniumpropylamino-4-hydroxyanthraquinone, methyl sulfate
Glossary names
Hydroxyanthraquinone-aminopropyl Methyl Morpholinium Methosulfate
CAS
38866-20-5
EC
254-161-9
Dates in the act (3)
  • Application from 10 August 2015
    It shall apply from 10 August 2015, except the provisions in point 2 of the Annex which shall apply from 10 August 2016.
  • Entry into force on 10 August 2015
  • Application from 10 August 2016
    It shall apply from 10 August 2015, except the provisions in point 2 of the Annex which shall apply from 10 August 2016.

Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.

Regulation (EC) No 1223/2009, Annex III, entry 293. CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.

Entry from Regulation (EU) 2015/1190, adopted on 20 July 2015.

What has changed, and what will change

Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.

  1. Annex II, entry 344: introduced or replaced by Regulation (EC) No 1223/2009

  2. Annex II, entry 344: applies from this date

  3. Annex III, entry 293: introduced or replaced by Regulation (EU) 2015/1190

  4. Annex III, entry 293: applies from this date

Identity

CosIng identifier
34478
CAS (according to CosIng)
38866-20-5
EC (according to CosIng)
254-161-9
Declared functions
Hair dyeing
Wikidata
Q27288209
ECHA InfoCard
100.049.221
InChIKey
JAADWTSKUWWHLE-UHFFFAOYSA-N

CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.

Wikidata, items with a CosIng identifier (P3073), retrieved 22 October 2026.

Wikidata, PubChem and ECHA links are published only when verified: same CosIng identifier, a single item, matching CAS number.

Elsewhere in the world

Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.

Comparison between countries

Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.

Comparison between countries: HYDROXYANTHRAQUINONEAMINOPROPYL METHYL MORPHOLINIUM METHOSULFATE
CountryRuleMaximum concentration cited
European UnionProhibited in cosmetics0.5%
United KingdomProhibited in cosmetics0.5%
SwitzerlandEU Regulation applies0.5%
United States (federal)No federal rule recordednot cited
CanadaNo entry in the lists recordednot cited
JapanNo entry in the lists recordednot cited
South KoreaNo entry in the lists recordednot cited
ChinaNot on the prohibited lists recorded (lists of allowed substances are not recorded)not cited
AustraliaNo entry in the lists recordednot cited
ASEANRestricted (conditions or maximum concentration) differs from the EU0.5%
TaiwanNo entry in the lists recordednot cited
BrazilNo entry in the lists recordednot cited

United Kingdom (Great Britain)

  • Prohibited in cosmetics (Annex II)
  • Allowed with restrictions (Annex III)

Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.

Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.

Contains public sector information licensed under the Open Government Licence v3.0.

Northern Ireland applies EU law.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.

The eCFR is not an official legal edition of the Code of Federal Regulations.

ASEAN (South-East Asia)

  • Restricted (conditions or maximum concentration): 1-N-Methylmorpholiniumpropylamino-4-hydroxyanthraquinone, methyl sulfate Hydroxyanthraquinone-aminopropyl Methyl Morpholinium Methosulfate

    Annex III (restricted substances), entry 308, page 234. Limit: 0.5%.

    Conditions, source text

    Ref column: (293) | Field of application and/or use: Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. | Other limitations and requirements: —Do not use with nitrosating agents —Maximum nitrosamine content: 50 μg/kg(21) — Keep in nitrite-free containers The direction for use “wear suitable gloves” must be included in label or leaflet text. | Conditions of use and warning which must be printed on the labels: To be printed on the label: “ Hair colorants can cause severe allergic reactions Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, —you have experienced a reaction to a temporary “black henna” tattoo in the past. Do not use to dye eyelashes or eyebrows

ASEAN Cosmetic Directive, Annexes II, III, IV, VI and VII (version 2026-1 of 22 June 2026, Annex VII 2025-2), retrieved 24 October 2026.

Source: ASEAN Cosmetic Documents, Annexes of the ASEAN Cosmetic Directive, as published by the Health Sciences Authority (HSA, Singapore); table extracted and formatted by the publisher of this site, with no endorsement by HSA or ASEAN.

Recorded cosmetics that contain it

3 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).

Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.

Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.

Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.

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