MUSK XYLENE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 16999
- Allowed with restrictions (Annex III)
MUSK XYLENE: Allowed with restrictions, with limits depending on the product type (Annex III, entry 96), under Regulation (EC) No 1223/2009. Good to know: hazardous to the aquatic environment. Annexes of the Regulation consulted on 21 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.
Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment. Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1); hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1).
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
In plain words
What it is used for
Functions declared by manufacturers:
Fragrance.
Perfuming.
What the rules say
Allowed, with restrictions: Annex III sets a maximum concentration and the product types allowed. Ingredient lists do not give quantities, so the concentration cannot be checked on the label.
Hazard and risk
The CLP Regulation classifies this substance as carcinogenic, category 2 (suspected effect, without enough evidence for a higher category).
This classification describes what the substance can cause (a hazard), not what happens when using a product (a risk): the risk depends on the dose, the form and the route of exposure (skin, inhalation, ingestion).
Classified as a category 2 CMRCarcinogenic, mutagenic (damages DNA) or toxic for reproduction. and allowed under the conditions of Annex III, after an SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. assessment.
The text of the annexes
Allowed with restrictions
- Product type
- All cosmetic products, with the exception of oral products Note: 'Due to environmental concerns, musk xylene is included in the authorisation list (Annex IV) of REACH. Musk xylene cannot be placed on the market or used unless authorisation has been granted under REACH’
- Maximum concentration
- (a) 1.0% in fine fragrance (b) 0.4% in eau de toilette (c) 0.03% in other products
- Entry
- Annex III, No 96
- Substance
- 5-tert-Butyl-2,4,6-trinitro-m-xylene
- Glossary names
- MUSK XYLENE
- CAS
- 81-15-2
- EC
- 201-329-4
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex III, entry 96: introduced or replaced by Regulation (EC) No 1223/2009
Annex III, entry 96: applies from this date
CLP classification “Carc. 2” applicable at the latest from this date (Regulation (EU) 2018/669)
Identity
- CosIng identifier
- 56999
- CAS (according to CosIng)
- 81-15-2
- EC (according to CosIng)
- 201-329-4
- Declared functions
- Fragrance, Perfuming
- Wikidata
- Q425330
- PubChem
- 62329
- ECHAEuropean Chemicals Agency. InfoCard
- 100.001.210
- InChIKey
- XMWRWTSZNLOZFN-UHFFFAOYSA-N
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
musk xylene; 5-tert-butyl-2,4,6-trinitro-m-xylene
Carcinogenicity, category 2 (Carc. 2)
- Hazard classes
- Explosive, category 1.1 (Expl. 1.1)
Carcinogenicity, category 2 (Carc. 2)
Hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1)
Hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1) - Hazard statements
- H201 H351 H400 H410
- CLP notes
- T
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Allowed with restrictions | 0.03 to 1% |
| United Kingdom | Allowed with restrictions | 0.03 to 1% |
| Switzerland | EU Regulation applies | 0.03 to 1% |
| United States (federal) | No federal rule recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | Restricted differs from the EU | 0.03 to 8% |
| China | No entry in the lists recorded | not cited |
| Australia | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Restricted: 머스크자일렌 (MUSK XYLENE)
별표 2, 기타 (other substances with limits), entry 22, page 30-31. Limit: ․향수류 향료원액을 8% 초과하여 함유하는 제품에 1.0%,향료원액을 8% 이하로 함유하는 제품에 0.4% ․기타 제품에 0.03%.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.