Compoatlas

MUSK XYLENE

Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 16999

MUSK XYLENE: Allowed with restrictions, with limits depending on the product type (Annex III, entry 96), under Regulation (EC) No 1223/2009. Good to know: hazardous to the aquatic environment. Annexes of the Regulation consulted on 21 October 2026.

Who it concerns

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  • Pregnancy and breastfeeding

    No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.

  • Babies and children

    The Cosmetics Regulation sets no age-related condition for this ingredient.

  • Skin, eyes and allergies

    No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.

  • Environment

    Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.

    Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment. Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1); hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1).

  • Read on the label

    The Cosmetics Regulation requires no warning to be printed for this ingredient.

In plain words

What it is used for

Functions declared by manufacturers:

Fragrance.

Perfuming.

What the rules say

Allowed, with restrictions: Annex III sets a maximum concentration and the product types allowed. Ingredient lists do not give quantities, so the concentration cannot be checked on the label.

Hazard and risk

The CLP Regulation classifies this substance as carcinogenic, category 2 (suspected effect, without enough evidence for a higher category).

This classification describes what the substance can cause (a hazard), not what happens when using a product (a risk): the risk depends on the dose, the form and the route of exposure (skin, inhalation, ingestion).

Classified as a category 2 CMRCarcinogenic, mutagenic (damages DNA) or toxic for reproduction. and allowed under the conditions of Annex III, after an SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. assessment.

The text of the annexes

Allowed with restrictions

Product type
All cosmetic products, with the exception of oral products Note: 'Due to environmental concerns, musk xylene is included in the authorisation list (Annex IV) of REACH. Musk xylene cannot be placed on the market or used unless authorisation has been granted under REACH’
Maximum concentration
(a) 1.0% in fine fragrance (b) 0.4% in eau de toilette (c) 0.03% in other products
Entry
Annex III, No 96
Substance
5-tert-Butyl-2,4,6-trinitro-m-xylene
Glossary names
MUSK XYLENE
CAS
81-15-2
EC
201-329-4

What has changed, and what will change

Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.

  1. Annex III, entry 96: introduced or replaced by Regulation (EC) No 1223/2009

  2. Annex III, entry 96: applies from this date

  3. CLP classification “Carc. 2” applicable at the latest from this date (Regulation (EU) 2018/669)

Identity

CosIng identifier
56999
CAS (according to CosIng)
81-15-2
EC (according to CosIng)
201-329-4
Declared functions
Fragrance, Perfuming
Wikidata
Q425330
PubChem
62329
ECHAEuropean Chemicals Agency. InfoCard
100.001.210
InChIKey
XMWRWTSZNLOZFN-UHFFFAOYSA-N

Classified hazard (CLP Regulation)

The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.

musk xylene; 5-tert-butyl-2,4,6-trinitro-m-xylene

Carcinogenicity, category 2 (Carc. 2)

Hazard classes
Explosive, category 1.1 (Expl. 1.1)
Carcinogenicity, category 2 (Carc. 2)
Hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1)
Hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1)
Hazard statements
H201 H351 H400 H410
CLP notes
T

Elsewhere in the world

Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.

Comparison between countries

Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.

CountryRuleMaximum concentration cited
European UnionAllowed with restrictions0.03 to 1%
United KingdomAllowed with restrictions0.03 to 1%
SwitzerlandEU Regulation applies0.03 to 1%
United States (federal)No federal rule recordednot cited
JapanNo entry in the lists recordednot cited
South KoreaRestricted differs from the EU0.03 to 8%
ChinaNo entry in the lists recordednot cited
AustraliaNo entry in the lists recordednot cited
BrazilNo entry in the lists recordednot cited

United Kingdom (Great Britain)

  • Allowed with restrictions (Annex III)

Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

South Korea

  • Restricted: 머스크자일렌 (MUSK XYLENE)

    별표 2, 기타 (other substances with limits), entry 22, page 30-31. Limit: ․향수류 향료원액을 8% 초과하여 함유하는 제품에 1.0%,향료원액을 8% 이하로 함유하는 제품에 0.4% ․기타 제품에 0.03%.

Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.