OXYQUINOLINE
Official label name (INCI name, EU glossary of cosmetic ingredient names), No 18547
- Prohibited, with exceptions (Annex II)
OXYQUINOLINE: Prohibited, with exceptions (Annex II, entry 395), under Regulation (EC) No 1223/2009.
In plain words
What it is used for
Functions declared by manufacturers:
Antimicrobial: helps control the growth of micro-organisms on the skin.
Chelating: reacts and forms complexes with metal ions which could affect the stability and/or appearance of cosmetics.
What the rules say
Prohibited, with the exceptions set out in the official title: "Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III".
Hazard and risk
The CLP Regulation classifies this substance as toxic for reproduction, category 1B (presumed effect, established mainly from animal studies).
This classification describes what the substance can cause (a hazard), not what happens when using a product (a risk): the risk depends on the dose, the form and the route of exposure (skin, inhalation, ingestion).
Already covered by an Annex II entry of the Cosmetics Regulation, which prohibits it only in certain cases, detailed above on this page.
The text of the annexes
Prohibited, with exceptions
CosIng links the name OXYQUINOLINE to this entry. The cases of prohibition are explained above, in “In plain words”; the official title is given below.
- Entry
- Annex II, No 395
- Substance
- Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III
- CAS
- 148-24-3 [1]; 134-31-6 [2]
- EC
- 205-711-1 [1]; 205-137-1 [2]
- CMR
- Reprotoxic Cat. 1B()
Dates in the act (5)
- Application from 11 June 2019
Points (1)(a) and (2)(b) of Annex II shall apply from 11 June 2019.
- Entry into force on 11 June 2019
- Entry into force on 18 December 2019
- Application from 1 May 2020
Article 1 shall apply from 1 May 2020.
- Entry into force on 1 May 2020
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Identity
- CosIng identifier
- 35773
- CAS (according to CosIng)
- 148-24-3
- EC (according to CosIng)
- 205-711-1
- Declared functions
- Antimicrobial, Chelating
- Wikidata
- Q270162
- PubChem
- 1923
- ECHA InfoCard
- 100.005.193
- InChIKey
- MCJGNVYPOGVAJF-UHFFFAOYSA-N
Classified hazard (CLP Regulation)
A classification describes an intrinsic hazard, not a risk: the risk depends on the dose, the form and the exposure.
quinolin-8-ol; 8-hydroxyquinoline
CMR Repr. 1B
- Hazard classes
- Repr. 1B
Acute Tox. 3
Eye Dam. 1
Skin Sens. 1
Aquatic Acute 1
Aquatic Chronic 1 - Hazard statements
- H360D H301 H318 H317 H400 H410
Already covered by an Annex II entry of the Cosmetics Regulation, which prohibits it only in certain cases, detailed above on this page.
Elsewhere in the world
Information on other jurisdictions. What is covered, and what is not yet.
United Kingdom (Great Britain)
- Prohibited, with exceptions (Annex II)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Prohibited: 옥시퀴놀린(히드록시-8-퀴놀린 또는 퀴놀린-8-올) 및 그 황산염 (OXYQUINOLINE)
별표 1 (prohibited substances), entry 635, page 34. Conditions (source text, in Korean): 화학물질명: 옥시퀴놀린(히드록시-8-퀴놀린 또는 퀴놀린-8-올) (CAS No. 148-24-3) | 화학물질명: 옥시퀴놀린 설페이트 (CAS No. 134-31-6)
China
- Prohibited: 8-羟基喹啉及其硫酸盐（化妆品限用组分中的8-羟基喹啉硫酸盐除外） (Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products)
表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 834, page 附件2 (.doc) table row 834 ; TID reprint p.33.
Brazil
- Prohibited: Hidroxi-8-quinolina e seu sulfato, exceto os mencionados em outras listas de substâncias
RDC 529/2021, Anexo (prohibited substances), entry 395, page 15. Conditions (source text, in Portuguese): N° UE: 395
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.