P-PHENYLENEDIAMINE HCl (p-phenylenediamine dihydrochloride)

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

• Pregnancy and breastfeeding

  No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.

• Babies and children

  The Cosmetics Regulation sets no age-related condition for this ingredient.

• Skin, eyes and allergies

  Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.

  Worth watching Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: eye irritation, category 2 (Eye Irrit. 2); skin sensitisation, category 1 (Skin Sens. 1).

• Environment

  Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.

  Worth watching Classified under the CLP Regulation: hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1); hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1).

• Read on the label

  For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  For information Annex III, entry 8a, requires this to be printed on the pack: “(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines. Do not use to dye eyelashes or eyebrows.’ (b)…”.

  For information Annex III, entry 8b, requires this to be printed on the pack: “To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into…”.

Allowed with restrictions

This entry covers the same substance as P-PHENYLENEDIAMINE HCl (same CAS number in the CosIng inventory): its conditions apply.

Product type

Hair dye substance in oxidative hair dye products

Other conditions

(a) General use (b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2 % calculated as free base

Warning to print

(a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines. Do not use to dye eyelashes or eyebrows.’ (b) To be printed on the label: The mixing ratio. ‘For professional use only. Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines. Wear suitable gloves.’

Entry

Annex III, No 8a

Substance

p-Phenylenediamine and its salts

CAS

106-50-3 / 624-18-0 / 16245-77-5

EC

203-404-7 / 210-834-9 / 240-357-1

Allowed with restrictions

Product type

Products intended for colouring eyelashes

Other conditions

After mixing under oxidative conditions the maximum concentration applied to eyelashes must not exceed 2 % calculated as free base. For professional use only.

Warning to print

To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them. Contains phenylenediamines. Wear suitable gloves.” ’

Entry

Annex III, No 8b

Substance

p- Phenylene-diamine and its salts

Glossary names

p-Phenylenediamine; p-Phenylenediamine HCl; p-Phenylenediamine Sulphate

CAS

106-50-3 / 624-18-0 / 16245-77-5

EC

203-404-7 / 210-834-9 / 240-357-1

Identity

CosIng identifier

37250

CAS (according to CosIng)

624-18-0

EC (according to CosIng)

210-834-9

Declared functions

Hair dyeing

Wikidata

Q3318029

ECHA InfoCard

100.009.850

InChIKey

IYXMNTLBLQNMLM-UHFFFAOYSA-N

benzene-1,4-diamine dihydrochloride; p-phenylenediamine dihydrochloride

Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification

Hazard classes

Acute toxicity, category 3 (Acute Tox. 3)
Eye irritation, category 2 (Eye Irrit. 2)
Skin sensitisation, category 1 (Skin Sens. 1)
Hazardous to the aquatic environment, short term, category 1 (Aquatic Acute 1)
Hazardous to the aquatic environment, long term, category 1 (Aquatic Chronic 1)

Hazard statements

H331 H311 H301 H319 H317 H400 H410

United Kingdom (Great Britain)

• Allowed with restrictions (Annex III)

Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

Canada

• Restricted (conditions or maximum concentration): p-Phénylènediamine et ses sels (p-Phenylenediamine and its salts)

  Hotlist, restricted ingredients. a) Not permitted in products intended for use on the skin. Additionally see "Coal tar dye". | b) Oxidative hair dyes: maximum concentration 3% after dilution with an oxidizer | Synonyms and related compounds: p-Phenylenediamine HCL; p-Phenylenediamine sulfate

South Korea

• Prohibited: 염산 p-페닐렌디아민

  별표 1 (prohibited substances), entry 906, page 46.

  Conditions, source text, in Korean

  ※ 유의사항 2: 1) 표시는 [별표 2] 염모제 성분에서 정한 기준에 적합한 경우는 제외한다.

• Restricted: 염산 p-페닐렌디아민

  별표 2, 염모제 성분 (hair colorants), entry 11, page 18. Limit: 산화염모제에 3.3%.

  Conditions, source text, in Korean

  비고: 기타 제품에는 사용금지

ASEAN (South-East Asia)

• Restricted (conditions or maximum concentration): p-Phenylenediamine and its salts p-Phenylenediamine; p-Phenylenediamine HCl; p-Phenylenediamine Sulphate

  Annex III (restricted substances), entry 8a, page 108.

  Conditions, source text

  Field of application and/or use: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. | Other limitations and requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2 % calculated as free base The direction for use “wear suitable gloves” must be included in label or leaflet text. | Conditions of use and warning which must be printed on the labels: To be printed on the label The mixing ratio. “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines. Do not use to dye eyelashes or eyebrows.’

Taiwan

• Restricted (conditions or maximum concentration): p-Phenylenediamine and its salts

  化粧品成分使用限制表 (restricted substances). Limit: 2% (以free base計).

  Conditions, source text, in Chinese

  INCI：p-Phenylenediamine ; p-Phenylenediamine HCl ; p-Phenylenediamine sulfate | 產品類型／使用範圍：氧化性染髮產品