TOLUENE-2,5-DIAMINE

What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.

Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

• Pregnancy and breastfeeding

  No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.

• Babies and children

  The Cosmetics Regulation sets no age-related condition for this ingredient.

• Skin, eyes and allergies

  Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.

  Worth watching Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: skin sensitisation, category 1 (Skin Sens. 1).

• Environment

  For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  For information Classified under the CLP Regulation: hazardous to the aquatic environment, long term, category 2 (Aquatic Chronic 2).

• Read on the label

  For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.

  For information Annex III, entry 9a, requires this to be printed on the pack: “(a) To be printed on the label: The mixing ratio. ' Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines (toluenediamines) (a) (i) Do not use to dye…”.

Allowed with restrictions

This entry covers the same substance as TOLUENE-2,5-DIAMINE (same CAS number in the CosIng inventory): its conditions apply.

Product type

(a) Products intended for colouring eyelashes (b) Products intended for colouring eyelashes

Other conditions

(a) (i) General use (a) (ii) Professional use (b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 2,0 % (cal­culated as free base) or 3,6 % (calculated as sulfate salt)

Warning to print

(a) To be printed on the label: The mixing ratio. ' Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. Contains phenylenediamines (toluenediamines) (a) (i) Do not use to dye eyelashes. (a) (ii) Wear suitable gloves. For professional use only.’ (b) As from 3 March 2018, to be printed on the label: The mixing ratio. ' This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary “black henna” tattoo in the past. Rinse eyes immediately if product comes into contact with them. Contains phenylenediamines (toluenediamines). Wear suitable gloves. For professional use only’.

Entry

Annex III, No 9a

Substance

Toluene-2,5-diamine Toluene-2,5-diamine sulphate

CAS

95-70-5 / 615-50-9

EC

202-442-1 / 210-431-8

Identity

CosIng identifier

38635

CAS (according to CosIng)

95-70-5

EC (according to CosIng)

202-442-1

Declared functions

Hair dyeing

Wikidata

Q2521416

PubChem

7252

ECHA InfoCard

100.002.221

InChIKey

OBCSAIDCZQSFQH-UHFFFAOYSA-N

2-methyl-p-phenylenediamine; 2,5-toluenediamine

Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification

Hazard classes

Acute toxicity, category 3 (Acute Tox. 3)
Acute toxicity, category 4 (Acute Tox. 4)
Skin sensitisation, category 1 (Skin Sens. 1)
Hazardous to the aquatic environment, long term, category 2 (Aquatic Chronic 2)

Hazard statements

H301 H332 H312 H317 H411

• 23 October 2026: Shampoo, Polar Hair Care, Sweden (“Serious risk”) alert
  According to the list of ingredients, the product contains p-phenylenediamine (PPD), toluene-2,5-diamine, p-aminophenol, m-aminophenol, 4-amino-2-hydroxytoluene, 1-naphthol and 4-amino-m-cresol, which are prohibited in shampoos. These substances can cause an…
• 23 October 2026: Shampoo, Polar Hair Care, Sweden (“Serious risk”) alert
  According to the list of ingredients, the product contains p-phenylenediamine (PPD), m-aminophenol, toluene-2,5-diamine sulphate, 4-amino-m-cresol, p-aminophenol, 4-amino-2-hydroxytoluene and 1-naphthol, which are prohibited in shampoos. These substances can…
• 8 July 2022: Hair dye, Royal, Germany (“Serious risk”) alert
  The product contains Toluene-2,5-Diamine, 5-Amino-o-cresol, p-aminophenol and p-phenylenediamine (PPD)(measured values: 0.2%, 0.8%, 4.1% and 2.7%, respectively) with an insufficient coupling agent. Toluene-2,5-Diamine, 5-Amino-o-cresol,, and uncoupled…

United Kingdom (Great Britain)

• Allowed with restrictions (Annex III)

Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

Canada

• Restricted (conditions or maximum concentration): Colorants d'aniline, leucobases et intermédiaires de colorant d'aniline (Coal tar dye)

  Hotlist, restricted ingredients. a) Not permitted in the area of the eye as indicated in section 14 of the Cosmetic Regulations. | b) In hair dyes as indicated in section 22 of the Cosmetic Regulations. | Synonyms and related compounds: Toluene-2,5-diamine; Toluene-2,5-diamine sulfate; See also “p-Phenylenediamine and its salts”

South Korea

• Prohibited: 톨루엔-2,5-디아민 (TOLUENE-2,5-DIAMINE)

  별표 1 (prohibited substances), entry 818, page 42.

  Conditions, source text, in Korean

  ※ 유의사항 2: 1) 표시는 [별표 2] 염모제 성분에서 정한 기준에 적합한 경우는 제외한다.

• Restricted: 톨루엔-2,5-디아민 (TOLUENE-2,5-DIAMINE)

  별표 2, 염모제 성분 (hair colorants), entry 13, page 18. Limit: 산화염모제에 2.0%.

  Conditions, source text, in Korean

  비고: 기타 제품에는 사용금지

ASEAN (South-East Asia)

• Restricted (conditions or maximum concentration): 1,4-Benzenediamine, 2- methyl-2,5-Diaminotoluene sulphate Toluene-2,5-Diamine Toluene-2,5-diamine sulphate

  Annex III (restricted substances), entry 9a, page 110.

  Conditions, source text

  Field of application and/or use: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. | Other limitations and requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2% (calculated as free base) or 3.6% (calculated as sulfate salt) The direction for use “wear suitable gloves” must be included in label or leaflet text. | Conditions of use and warning which must be printed on the labels: To be printed on the label: The mixing ratio Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Do not use to dye eyelashes or eyebrows.

Taiwan

• Restricted (conditions or maximum concentration): 1,4-Benzenediamine, 2-methyl-/ 2,5-Diaminotoluene sulphate

  化粧品成分使用限制表 (restricted substances). Limit: 2% (以free base計) 3.6% (以sulfate salt計).

  Conditions, source text, in Chinese

  INCI：Toluene-2,5-diamine ; Toluene-2,5-diamine sulfate | 產品類型／使用範圍：氧化性染髮產品

54 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).