System-Six
En vente sur le marché américain (selon le DSLD)
Irwin Naturals, food supplement from the US market
System-Six (Irwin Naturals), a food supplement au code-barres 710363262471, is described by its US market label. If sold in France, it would be subject to 4 points of French or European regulation, detailed below. Doses of niacine are not compared: their US units depend on the form. The formula sold in Europe under the same name may differ.
Official label. Dietary Supplement Label Database (DSLD), US National Institutes of Health: current and off-market labels, retrieved 27 October 2026.
Source: NIH Office of Dietary Supplements, Dietary Supplement Label Database (CC0); US market labels.
Displayed label: Official label. Labels on the market are prioritised, followed by the most recent for the same status.
If this product were sold in France
- Dose déclarée au-delà d'une limite
Chrome: up to 200 µg a day according to the label (at most 1 serving a day), above the maximum dose of 25 µg set in France for a food supplement (2006 Order, not revised since November 2006).
Source: French orders of 9 May 2006 and 14 November 2006 as published in the Official Journal (maximum daily doses), arrêté du 9 mai 2006, annexe III.
- Conditions légales
Contains tea (Camellia sinensis). Green tea extracts must provide less than 800 mg of epigallocatechin-3-gallate per daily portion, with mandatory warnings.
Source: Regulation (EC) No 1925/2006, latest consolidated version, annexe III, partie B (règlement (UE) 2022/2340).
- Conditions légales
Camellia sinensis (L.) Kuntze: Seules sont admises la poudre issue du broyage des feuilles et les préparations obtenues à partir des solvants suivants : l'eau, l'alcool à 25 % (v/v), ainsi que les solvants autorisés pour la décaféination ou la suppression des matières irritantes et amères. Les recommandations d'emploi ne doivent pas conduire à une ingestion quotidienne d'EGCG supérieure à 300 mg. L'étiquetage doit comporter des avertissements déconseillant leur prise en dehors des repas, ainsi que leur consommation par les enfants, les adolescents, les femmes enceintes ou allaitantes.
Source: French orders of 9 May 2006 (nutrients), 24 June 2014 (plants) and 26 September 2016 (other substances), consolidated LEGI collection, arrêté du 24 juin 2014, annexe I.
- Conditions légales
Citrus aurantium L.: La quantité ingérée de p-synéphrine doit être inférieure à 20 mg par dose journalière recommandée. L'étiquetage doit comporter un avertissement déconseillant l'emploi aux enfants, aux femmes enceintes ou allaitantes et en cas de traitement anti-hypertenseur. La caféine et les sources de caféine ne sont pas autorisées dans les compléments alimentaires contenant Citrus aurantium L.
Source: French orders of 9 May 2006 (nutrients), 24 June 2014 (plants) and 26 September 2016 (other substances), consolidated LEGI collection, arrêté du 24 juin 2014, annexe I.
A daily dose is calculated only if the label gives the maximum number of servings and a unit of mass (or international units for vitamin D). Quantities come from the label, not an analysis. In the United States, the label presents this product as a ‘dietary supplement’; in France, a product of this type may belong to another category (a sports powder, for example), and maximum food supplement doses do not apply to it.
Label composition
- Brand
- Irwin Naturals
- Barcode
- 710363262471
- Form
- Softgel
- One serving
- 6 softgels
- Servings
- up to 1 serving per day
- Other ingredients (in English, as written)
- Gelatin, purified Water, Glycerin, Soy Lecithin, Beeswax, Annatto, Turmeric, Titanium Dioxide, St. John's Bread, Sodium Copper Chlorophyllin
| Ingredient (as written, in English) | Category | Per serving |
|---|---|---|
| Vitamin C | Vitamin | 40 mg |
| Vitamin E | Vitamin | 10 UI |
| Thiamine | Vitamin | 1 mg |
| Riboflavin | Vitamin | 1 mg |
| Niacin | Vitamin | 14 mg |
| Vitamin B12 | Vitamin | 4 µg |
| Pantothenic Acid | Vitamin | 60 mg |
| Selenium | Mineral | 34 µg |
| Chromium | Mineral | 200 µg |
| Fish Oil | Fat | 3,053 mg |
| Garcinia extract (Garcinia mangostana) | Plant | 670 mg |
| White Tea extract (Camellia sinensis) | Plant | 600 mg |
| Green Tea extract (Camellia sinensis) | Plant | 375 mg |
| Caffeine | Other substance | 150 mg |
| Rhodiola extract | Plant | 340 mg |
| Advantra Z Bitter Orange extract (Citrus aurantium) | Plant | 200 mg |
| L-Carnitine | Other substance | 200 mg |
| L-Tyrosine | Amino acid | 100 mg |
| Choline | Vitamin | 60 mg |
| Inositol | Other substance | 60 mg |
| Cayenne powder (Capsicum annuum) | Plant | 40 mg |
| Ginger powder | Plant | 40 mg |
| Guarana (Paullinia cupana) powder | Plant | 40 mg |
| Mate (Yerba Mate) extract (Ilex paraguariensis) | Plant | 40 mg |
| Spirulina (Arthrospira platensis) powder | Micro-organism | 40 mg |
| Betaine | Other substance | 15 mg |
| BioPerine Complex | Blend | 6 mg |
| Bioperine Black Pepper extract (Piper nigrum) | Plant | not stated |
| Ginger extract | Plant | not stated |
Other versions of this label
The differences below describe each other version relative to the label shown on this page. They concern active ingredient rows and quantities per serving as written. Missing quantities are not estimated and different units are not converted. Dates refer to entry into DSLD, not necessarily to a formula change.
Official label: System-Six
Entered into DSLD on 25 June 2015. Retirée du marché américain le 7 May 2015 (selon le DSLD).- Active ingredient removed : Niacin (14 mg)
This information reproduces the US label recorded by the US National Institutes of Health (NIH). It does not say whether the product is effective and does not replace advice from a doctor or pharmacist, particularly during pregnancy or when taking medication.
Official warnings (Health Canada)
Health Canada publishes warnings on these ingredients:
- Fish Oil
Read the warning, when it applies and the studies cited
FISH OIL
Route of administration: Oral
Cautions and warnings
Condition of application: Pain of rheumatoid arthritis.
Ask a health care practitioner/health care provider/health care professional/doctor/physician if symptoms worsen.
Condition of application: Healthy mood balance.
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you have psychological disorders such as anxiety or depression.
- Caffeine
Read the warning, when it applies and the studies cited
CAFFEINE
Route of administration: Oral (Higdon and Frei 2006)
Cautions and warnings
Applies to products providing 100 mg to 400 mg caffeine, per day1.
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you have high blood pressure or glaucoma (Cornelis and El-Sohemy 2007, Chandrasekaran et al. 2005, Noordzij et al. 2005, Avisar et al. 2002, Arya et al. 2000, Jee et al. 1999, Creighton and Stanton 1990).
7 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
1Note: This statement is also required at subtherapeutic quantities for products providing 40 mg or more caffeine per day from all sources for Class II and III applications.
Applies to products providing more than 300 mg caffeine, per day.
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you are pregnant, breastfeeding, or attempting to conceive (Nawrot et al. 2003).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Applies to products providing 400 mg or more caffeine, per day.
When using this product avoid taking other health products, foods or beverages that contain caffeine and/or increase blood pressure (FDA 2023; Bui et al. 2006; Bouchard et al. 2005; Haller et al. 2005; NIH 2004; Berardi et al. 2002; Vahedi et al. 2000; Zimmerman 1992).
8 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
Contraindications
Applies to products providing more than 400 mg caffeine per day.
Do not use if you have high blood pressure or glaucoma (Cornelis and El-Sohemy 2007, Chandrasekaran et al. 2005, Noordzij et al. 2005, Avisar et al. 2002, Arya et al. 2000, Jee et al. 1999, Creighton and Stanton 1990).
7 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
Known adverse reactions
Condition of application: All products.
Stop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if hypersensitivity/allergy occurs (Infante et al. 2003; Hinrichs et al. 2002).
2 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
Applies to products providing 200 mg or more caffeine, per day.
Stop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if symptoms such as chest pain and irregular heartbeat occur (Higgins and Babu 2013).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Applies to products providing more than 400 mg caffeine, per day.
Stop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if nervousness, anxiety, insomnia, tremor and/or headache occur (IOM 2001, Zhang 2001, Sawynok 1995).
3 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
Condition of application: All products except those making a diuretic claim1.
When using this product diuretic effect may occur.
1Note: This statement is also required at subtherapeutic quantities for products providing 40 mg or more caffeine per day from all sources for Class II and III applications.
- L-Carnitine
Read the warning, when it applies and the studies cited
L-CARNITINE
Route of administration: Oral
Cautions and warnings
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you are pregnant or breastfeeding (CPS 2008).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a seizure disorder (CPS 2008).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
- Cayenne powder
Read the warning, when it applies and the studies cited
CAYENNE - CAPSICUM ANNUUM Oral
Cautions and warnings
Condition of application: All products.
Keep out of the reach of children. If overdose or accidental ingestion occurs, call a poison control centre or get medical help right away (CPS 2008).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you are pregnant or breastfeeding (Bradley 2006; Boon and Smith 2004).
2 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you have stomach ulcers or inflammation (Brinker 2010).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Condition of application: Digestion; Peripheral circulation.
Ask a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist or worsen.
Health Canada monograph dated 27 March 2026
CAYENNE - CAPSICUM ANNUUM/CAPSAICIN Topical
Cautions and warnings
Condition of application: All products.
For external use only (US FDA 2023).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
When using this product avoid contact with the eyes and mucous membranes. If contact occurs, rinse thoroughly with water (US FDA 2023).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Stop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist, worsen, or re-occur within a few days (US FDA 2023).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Keep out of the reach of children. If swallowed, call a poison control centre or get medical help right away (CPS 2008).
1 study cited in the text has no matching reference in the monograph (see the anomalies listed on the sources page).
Known adverse reactions
Condition of application: All products.
Stop use if headache, redness, rashes, burning discomfort and/or hypersensitivity occur (Brayfield and Cadart 2024; Zhang et al. 2008; Hoffman 2003; APhA 2002; McCleane 2000).
5 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
- Betaine
Read the warning, when it applies and the studies cited
BETAINE / BETAINE HYDROCHLORIDE
Route of administration: Oral
Cautions and warnings
Condition of application: All products.
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you are pregnant or breastfeeding.
Applies to products containing Betaine hydrochloride (as a medicinal ingredient or as a source ingredient).
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a peptic ulcer or excess stomach acid (RSC 2024; Hendler and Rorvik 2008).
2 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
Applies to products providing 600 milligrams or more of Betaine or 780 milligrams or more of Betaine hydrochloride as a medicinal ingredient, per day.
Ask a health care practitioner/health care provider/health care professional/doctor/physician before use if you have high cholesterol (Olthof et al. 2005; Swab et al. 2002).
2 studies cited in the text have no matching reference in the monograph (see the anomalies listed on the sources page).
They concern the ingredient, not this product or its dose. They do not replace medical advice.
List declared on (register: Dietary Supplement Label Database (DSLD), US National Institutes of Health: current and off-market labels).
Brand : Irwin Naturals
Is something on this product wrong or out of date, whether you are a reader or the brand? Write to contact@compoatlas.com: every correction is published in the corrections log.