2-METHOXYMETHYL-P-PHENYLENEDIAMINE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 228
- Cited as an example in a rule, no rule of its own (Annex III)
2-METHOXYMETHYL-P-PHENYLENEDIAMINE: Cited as an example in a rule, no rule of its own (Annex III, entry 292), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No harmonised classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
In plain words
What the rules say
This name is only cited as an example in an entry of Annex III, which covers a family of substances: the exact conditions depend on the form used.
CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Origin and odour
Present in 0.0% of recorded cosmetics (1 out of 22 609).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
The text of the annexes
Allowed with restrictions
CosIngThe European Commission's database of cosmetic ingredients. cites the name 2-METHOXYMETHYL-P-PHENYLENEDIAMINE in this entry, whose regulated name is “2-METHOXYMETHYL-P-PHENYLENEDIAMINE /2-METHOXYMETHYL-P-PHENYLENEDIAMINE SULFATE”: the title below says which form or use it covers.
| Product type | Other conditions | Warning to print |
|---|---|---|
| (a) Hair dye substance in oxidative hair dye products | After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 1,8 % (calculated as free base) | To be printed on the label: The mixing ratio. ‘! Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’ |
| (b) Products intended for colouring eyelashes | Professional use | To be printed on the label: The mixing ratio. ‘! This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp, — has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary “black henna” tattoo in the past. For professional use only. Rinse eyes immediately if product comes into contact with them.’ |
- Entry
- Annex III, No 292
- Substance
- 1,4-Benzenediamine, 2-(methoxymethyl) 1,4-Benzenediamine, 2-(methoxymethyl)-, sulfate
- Glossary names
- 2-METHOXYMETHYL-P-PHENYLENEDIAMINE /2-METHOXYMETHYL-P-PHENYLENEDIAMINE SULFATE
- CAS
- 337906-36-2 ; 337906-37-3
- EC
- 679-526-3; 638-749-6
Dates in the act (3)
- Entry into force on 3 December 2020
- Condition applicable from 3 June 2021
As from 3 June 2021: 0,5 % Methanesulfonates impurities, in particular ethyl methanesulfonate shall not be present
- Condition applicable from 3 December 2021
As from 3 December 2021, to be printed on the label: The mixing ratio
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Regulation (EC) No 1223/2009, Annex III, entry 292. CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EU) 2020/1683, adopted on 12 November 2020.
SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: Addendum to the scientific Opinion SCCS/1491/12 on the hair dye substance 2-methoxy-methyl-p-phenylenediamine and its sulfate salt COLIPA n°A160 Submission II –use on eyelashes; OPINION ON 2-Methoxy-methyl-p-phenylenediamine and its sulfate salt COLIPA n° A160.
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Cited as an example in a rule, no rule of its own | not cited |
| United Kingdom | Allowed with restrictions differs from the EU | not cited |
| Switzerland | EU Regulation applies | not cited |
| United States (federal) | No federal rule recorded | not cited |
| Canada | No entry in the lists recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | No entry in the lists recorded | not cited |
| China | Not on the prohibited lists recorded (lists of allowed substances are not recorded) | not cited |
| Australia | No entry in the lists recorded | not cited |
| ASEAN | No entry in the lists recorded | not cited |
| Taiwan | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
Recorded cosmetics that contain it
1 recorded product list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.