3-NITRO-P-HYDROXYETHYLAMINOPHENOL
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 297
- Allowed with restrictions (Annex III)
3-NITRO-P-HYDROXYETHYLAMINOPHENOL: Allowed with restrictions, with limits depending on the product type (Annex III, entry 248), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 21 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No official classification as hazardous to the aquatic environment and no assessment as an endocrine disruptor for the environment.
Read on the label
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance. Annex III, entry 248, requires this to be printed on the pack: “For (a) and (b): Hair colourants can use severe allergic reactions Read and follow intructions”.
In plain words
What it is used for
Functions declared by manufacturers:
Hair dyeing: colours hair.
What the rules say
Allowed, with restrictions: Annex III sets a maximum concentration, the product types allowed and a warning to be printed on the packaging. Ingredient lists do not give quantities, so the concentration cannot be checked on the label; the warning can.
The text of the annexes
Allowed with restrictions
| Product type | Maximum concentration | Other conditions |
|---|---|---|
| (a) Hair dye substance in oxidative hair dye products | not set | and |
| (b) Hair dye substance in non-oxidative hair dye products | 1.85% | : - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/Kg - Keep in nitrite-free containers |
- Warning to print
- For (a) and (b): Hair colourants can use severe allergic reactions Read and follow intructions
- Entry
- Annex III, No 248
- Substance
- 4-[(2-Hydroxyethyl)amino-3-nitrophenol
- Glossary names
- 3-NITRO-P-HYDROXYETHYLAMINOPHENOL
- CAS
- 65235-31-6
- EC
- 265-648-0
Dates in the act (3)
- Entry into force on 15 May 2013
- Application from 11 July 2013
It shall apply from 11 July 2013.
- Entry into force on 11 July 2013
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex III, entry 248: introduced or replaced by Regulation (EU) n° 344/2013
Annex III, entry 248: applies from this date
Identity
- CosIng identifier
- 31519
- CAS (according to CosIng)
- 65235-31-6
- EC (according to CosIng)
- 265-648-0
- Declared functions
- Hair dyeing
- Wikidata
- Q27273942
- PubChem
- 5488102
- ECHAEuropean Chemicals Agency. InfoCard
- 100.059.662
- InChIKey
- UXKLYBMQAHYULT-UHFFFAOYSA-N
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Allowed with restrictions | 1.85% |
| United Kingdom | Allowed with restrictions | 1.85% |
| Switzerland | EU Regulation applies | 1.85% |
| United States (federal) | No federal rule recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | Prohibited differs from the EU | 1.85 to 3% |
| China | No entry in the lists recorded | not cited |
| Australia | Subject to conditions (threshold, labelling or packaging) differs from the EU | 1.85 to 3% |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Prohibited: 4-(2-하이드록시에칠)아미노-3-니트로페놀 및 그 염류 (예 : 3-니트로-p-하이드록시에칠아미노페놀)
별표 1 (prohibited substances), entry 1027, page 52.
Conditions, source text, in Korean
화학물질명: 3-니트로-p-하이드록시에칠아미노페놀 (CAS No. 65235-31-6) | ※ 유의사항 2: 1) 표시는 [별표 2] 염모제 성분에서 정한 기준에 적합한 경우는 제외한다.
- Restricted: 3-니트로-p-하이드록시에칠아미노페놀
별표 2, 염모제 성분 (hair colorants), entry 71, page 25. Limit: ·산화염모제에 3.0% ·비산화염모제에 1.85%.
Conditions, source text, in Korean
비고: 기타제품에는 사용금지
Australia
- Subject to conditions (threshold, labelling or packaging): 3-NITRO-p-HYDROXYETHYLAMINOPHENOL
Poisons Standard, Schedule 6 (cosmetic entries), page 272. Thresholds cited: 1.85% or less | 3% or less.
Conditions, source text
except | (a) in non-oxidative hair dye preparations containing 1.85% or less of 3-nitro-p-hydroxyethylaminophenol after mixing when the immediate container and primary pack are labelled with the following statements: | (i) KEEP OUT OF REACH OF CHILDREN; and | (ii) WARNING – This product contains ingredients which may cause skin sensitisation to certain individuals. A preliminary test according to the accompanying directions should be made before use. This product must not be used for dyeing eyelashes or eyebrows; to do so may be injurious to the eye; | written in letters not less than 1.5 mm in height; or | (b) in oxidative hair dye preparations containing 3% or less of 3-nitro-p-hydroxyethylaminophenol after mixing under oxidative conditions when the immediate container and primary pack are labelled with the following statements: | (i) KEEP OUT OF REACH OF CHILDREN; and | (ii) WARNING – This product contains ingredients which may cause skin sensitisation to certain individuals. A preliminary test according to the accompanying directions should be made before use. This product must not be used for dyeing eyelashes or eyebrows; to do so may be injurious to the eye; | written in letters not less than 1.5 mm in height.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.