4-HYDROXYPROPYLAMINO-3-NITROPHENOL
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 333
- Allowed with restrictions (Annex III)
4-HYDROXYPROPYLAMINO-3-NITROPHENOL: Allowed with restrictions, with limits depending on the product type (Annex III, entry 205), under Regulation (EC) No 1223/2009. Good to know: hazardous to the aquatic environment. Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For information Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: skin irritation, category 2 (Skin Irrit. 2). This classification describes the pure substance; in a finished product it is far more diluted.
Environment
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For information Classified under the CLP Regulation: hazardous to the aquatic environment, long term, category 2 (Aquatic Chronic 2).
Read on the label
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For information Annex III, entry 205, requires a warning that depends on the type of product: Hair dye substance in oxidative hair dye products: “To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: —…”. None for: Hair dye substance in non-oxidative hair dye products.
For information Annex III, entry 219, requires a warning that depends on the type of product: Hair dye substance in oxidative hair dye products: “To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: —…”. None for: Hair dye substance in non-oxidative hair dye products.
Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
In plain words
What it is used for
Functions declared by manufacturers:
Hair dyeing: colours hair.
Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.
What the rules say
Allowed, with restrictions: Annex III sets a maximum concentration, the product types allowed and a warning to be printed on the packaging. Ingredient lists do not give quantities, so the concentration cannot be checked on the label; the warning can.
CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Origin and odour
No natural occurrence recorded in Wikidata (LOTUS database); this does not prove that the ingredient is synthetic.
Basis: one CosIng CAS, with no natural occurrence recorded in this database.
Wikidata: names of substances in six languages and taxa in which they occur (largely from the LOTUS database), retrieved 23 October 2026.
Present in 0.0% of recorded cosmetics (1 out of 19 871), mainly: shampoos.
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
The text of the annexes
Allowed with restrictions
| Product type | Maximum concentration | Other conditions | Warning to print |
|---|---|---|---|
| (a) Hair dye substance in oxidative hair dye products | not set | and | To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary 'black henna’ tattoo in the past. |
| (b) Hair dye substance in non-oxidative hair dye products | 2.6% | : - Do not use with nitrosating systems - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers | not set |
- Entry
- Annex III, No 205
- Substance
- 1-Hydroxy-3-nitro-4-(3-hydroxypropylamino)benzene (see note 17)
- Glossary names
- 4-HYDROXYPROPYLAMINO-3-NITROPHENOL
- CAS
- 92952-81-3
- EC
- 406-305-9
Dates in the act (2)
- Entry into force on 15 May 2013
- Application from 11 July 2013
It shall apply from 11 July 2013.
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Regulation (EC) No 1223/2009, Annex III, entry 205. CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EU) n° 344/2013, adopted on 4 April 2013.
SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: Request for a Re-evaluation of hair dyes listed in Annex III to Directive 76/768/EEC on Cosmetic Products; Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004; Opinion on Personal Use of Hair Dyes and Cancer Risk; Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk; Assessment Strategies for Hair Dyes; Opinion on 4-Hydroxypropylamino-3-nitrophenol; Opinion on 4-Hydroxypropylamino-3-nitrophenol; Memorandum on Hair Dye Substances and their Skin Sensitising Properties.
Allowed with restrictions
| Product type | Maximum concentration | Other conditions | Warning to print |
|---|---|---|---|
| (a) Hair dye substance in oxidative hair dye products | not set | and | To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’ |
| (b) Hair dye substance in non-oxidative hair dye products | 2.6% | : — Do not use with nitro sating agents — Maximum nitrosamine content: 50 μg /kg — Keep in nitrite-free containers | not set |
- Entry
- Annex III, No 219
- Substance
- 1-Hydroxy-3-nitro- 4-(3-hydroxypropy lamino)benzene
- Glossary names
- 4-Hydroxypropylamino-3-nitrophenol
- CAS
- 92952-81-3
- EC
- 406-305-9
Regulation (EC) No 1223/2009, Annex III, entry 219. CosIng, Annex III of Regulation (EC) No 1223/2009 (restricted substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EC) No 1223/2009, adopted on 30 November 2009. Last amended by Regulation (EU) n° 344/2013 (consolidated version, EUR-Lex).
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex III, entry 219: introduced or replaced by Regulation (EC) No 1223/2009
Annex III, entry 205: introduced or replaced by Regulation (EU) n° 344/2013
Annex III, entry 205: applies from this date
Annex III, entry 219: applies from this date
CLP classification “Skin Irrit. 2” applicable at the latest from this date (Regulation (EU) 2018/669)
Identity
- CosIng identifier
- 31528
- CAS (according to CosIng)
- 92952-81-3
- EC (according to CosIng)
- 406-305-9
- Declared functions
- Hair dyeing
- Wikidata
- Q27293680
- PubChem
- 5463795
- ECHA InfoCard
- 100.100.790
- InChIKey
- VTXBLQLZQLHDIL-UHFFFAOYSA-N
CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Wikidata, items with a CosIng identifier (P3073), retrieved 22 October 2026.
Wikidata, PubChem and ECHAEuropean Chemicals Agency. links are published only when verified: same CosIng identifier, a single item, matching CAS number.
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
4-[(3-hydroxypropyl)amino]-3-nitrophenol
Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification
- Hazard classes
- Skin irritation, category 2 (Skin Irrit. 2)
Hazardous to the aquatic environment, long term, category 2 (Aquatic Chronic 2) - Hazard statements
- H315 H411
Annex VI, entry 609-060-00-8, linked by CAS 92952-81-3. Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
Entry introduced or replaced by Regulation (EU) 2018/669, applicable at the latest from 1 December 2019.
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Allowed with restrictions | 2.6% |
| United Kingdom | Allowed with restrictions | 2.6% |
| Switzerland | EU Regulation applies | 2.6% |
| United States (federal) | No federal rule recorded | not cited |
| Canada | No entry in the lists recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | Prohibited differs from the EU | 2.6% |
| China | Not on the prohibited lists recorded (lists of allowed substances are not recorded) | not cited |
| Australia | No entry in the lists recorded | not cited |
| ASEAN | Restricted (conditions or maximum concentration) | 2.6% |
| Taiwan | Restricted (conditions or maximum concentration) | 2.6% |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
South Korea
- Prohibited: 1-하이드록시-3-니트로-4-(3-하이드록시프로필아미노)벤젠 및 그 염류(예 : 4-하이드록시프로필아미노-3-니트로페놀) (4-HYDROXYPROPYLAMINO-3-NITROPHENOL)
별표 1 (prohibited substances), entry 1017, page 51.
Conditions, source text, in Korean
화학물질명: 4-하이드록시프로필아미노-3-니트로페놀 (CAS No. 92952-81-3) | ※ 유의사항 2: 1) 표시는 [별표 2] 염모제 성분에서 정한 기준에 적합한 경우는 제외한다.
- Restricted: 1-하이드록시-3-니트로-4-(3-하이드록시프로필아미노)벤젠및그염류 (4-HYDROXYPROPYLAMINO-3-NITROPHENOL)
별표 2, 염모제 성분 (hair colorants), entry 68, page 24. Limit: 2.6%.
Conditions, source text, in Korean
비고: 기타제품에는 사용금지 | 화학물질명: 4-하이드록시프로필아미노-3-니트로페놀 (CAS No. 92952-81-3)
South Korea, MFDS Regulation on Safety Standards for Cosmetics, Notification 2026-19, retrieved 22 October 2026.
Source: 식품의약품안전처 (MFDS), 화장품 안전기준 등에 관한 규정, via law.go.kr; table formatted by the publisher of this site.
ASEAN (South-East Asia)
- Restricted (conditions or maximum concentration): 1-Hydroxy-3-nitro-4-(3-hydroxypropylamino)benzene 4-Hydroxypropylamino-3-nitrophenol
Annex III (restricted substances), entry 205, page 153. Limit: (b) 2.6%.
Conditions, source text
Ref column: (219) EU 344/2013 | Field of application and/or use: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. | Other limitations and requirements: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.6 % calculated as free base. For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg(21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use “wear suitable gloves” must be included in label or leaflet text. | Conditions of use and warning which must be printed on the labels: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows
ASEAN Cosmetic Directive, Annexes II, III, IV, VI and VII (version 2026-1 of 22 June 2026, Annex VII 2025-2), retrieved 24 October 2026.
Source: ASEAN Cosmetic Documents, Annexes of the ASEAN Cosmetic Directive, as published by the Health Sciences Authority (HSA, Singapore); table extracted and formatted by the publisher of this site, with no endorsement by HSA or ASEAN.
Taiwan
- Restricted (conditions or maximum concentration): 1-Hydroxy-3-nitro-4-(3-hydroxypropylamino)benzene (4-Hydroxypropylamino-3-nitrophenol)
化粧品成分使用限制表 (restricted substances). Limit: (a)2.6% (b)2.6%.
Conditions, source text, in Chinese
產品類型／使用範圍：(a)氧化性染髮產品 (b)非氧化性染髮產品 | 限制規定：不得與亞硝基化劑一起使用; 亞硝胺限量:50 microgram/kg (ppb); 應置於無亞硝基酸鹽之容器
Taiwan, TFDA cosmetic ingredient tables (prohibited, restricted, preservatives, UV filters, colorants), open data, retrieved 24 October 2026.
Source: Taiwan Food and Drug Administration (TFDA), open datasets on data.gov.tw (Open Government Data License, version 1.0); table formatted by the publisher of this site.
Recorded cosmetics that contain it
1 recorded product list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.