6-HYDROXYINDOLE
Official label name (INCI name, EU glossary of cosmetic ingredient names), No 374
- Allowed with restrictions (Annex III)
6-HYDROXYINDOLE: Allowed with restrictions (Annex III, entry 209), under Regulation (EC) No 1223/2009.
In plain words
What it is used for
Functions declared by manufacturers:
Hair dyeing: colours hair.
What the rules say
Allowed, with restrictions: Annex III sets the product types allowed and a warning to be printed on the packaging. Ingredient lists do not give quantities, so the concentration cannot be checked on the label; the warning can.
The text of the annexes
Allowed with restrictions
This entry covers the same substance as 6-HYDROXYINDOLE (same CAS number in the CosIng inventory): its conditions apply.
- Entry
- Annex III, No 209
- Substance
- 1H-Indol-6-ol
- Glossary names
- 6-Hydroxy-indole
- CAS
- 2380-86-1
- EC
- 417-020-4
- Product type
- Hair dye substance in oxidative hair dye products
- Other conditions
- After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,5%.
- Warnings
- To be printied on the label: Hair colorants can cause severe allergic reactions.
Dates in the act (4)
- Application from 11 July 2013
etic products (1), and in particular Article 31(1) thereof, Whereas: (1) Regulation (EC) No 1223/2009 replacing Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products (2) will apply from 11 July 2013.
- Entry into force on 31 July 2013
- Application from 1 September 2013
It shall apply from 1 September 2013.
- Entry into force on 1 September 2013
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Identity
- CosIng identifier
- 31541
- CAS (according to CosIng)
- 2380-86-1
- EC (according to CosIng)
- 417-020-4
- Declared functions
- Hair dyeing
- Wikidata
- Q27257236
- PubChem
- 524508
- ECHA InfoCard
- 100.101.589
- InChIKey
- XAWPKHNOFIWWNZ-UHFFFAOYSA-N
Classified hazard (CLP Regulation)
A classification describes an intrinsic hazard, not a risk: the risk depends on the dose, the form and the exposure.
6-hydroxyindole
No harmonised CMR classification
- Hazard classes
- Acute Tox. 4 *
Eye Dam. 1
Skin Sens. 1
Aquatic Chronic 2 - Hazard statements
- H302 H318 H317 H411
Elsewhere in the world
Information on other jurisdictions. What is covered, and what is not yet.
United Kingdom (Great Britain)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Prohibited: 6-히드록시인돌 (6-HYDROXYINDOLE)
별표 1 (prohibited substances), entry 1035, page 52. Conditions (source text, in Korean): ※ 유의사항 2: 1) 표시는 [별표 2] 염모제 성분에서 정한 기준에 적합한 경우는 제외한다.
- Restricted: 6-히드록시인돌 (6-HYDROXYINDOLE)
별표 2, 염모제 성분 (hair colorants), entry 31, page 20. Limit: 산화염모제에 0.5 %. Conditions (source text, in Korean): 비고: 기타 제품에는 사용금지
Recorded cosmetics that contain it
9 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (page in French).
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.