DIISOPROPANOLAMINE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 8776
- Prohibited in cosmetics (Annex II)
DIISOPROPANOLAMINE: Prohibited in cosmetics (Annex II, entry 411), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
This ingredient is prohibited in cosmetics in the European Union: what follows describes its hazards, not a permitted use.
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.
Babies and children
Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.
Skin, eyes and allergies
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For information Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: eye irritation, category 2 (Eye Irrit. 2). This classification describes the pure substance; in a finished product it is far more diluted.
Environment
No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
In plain words
What it is used for
Functions declared by manufacturers:
Buffering: stabilises the pH of cosmetics.
Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.
What the rules say
It is prohibited to use it in a cosmetic product sold in the European Union, whatever the dose. If it appears on the ingredient list of a recent product, this needs checking: the record may be old or wrong, or the product intended for another market.
CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.
The text of the annexes
Prohibited in cosmetics
CosIng links the name DIISOPROPANOLAMINE to this Annex II entry.
- Entry
- Annex II, No 411
- Substance
- Secondary alkyl- and alkanolamines and their salts
- CAS
- 111-42-2 / 110-97-4
- EC
- 203-868-0 / 203-820-9
Regulation (EC) No 1223/2009, Annex II, entry 411. CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EC) No 1223/2009, adopted on 30 November 2009.
SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: Opinion concerning Dialkyl- and Dialkanolamines and their salts in cosmetic products; Opinion concerning banning of Dialkanolamines which are still in the inventory.
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex II, entry 411: introduced or replaced by Regulation (EC) No 1223/2009
Annex II, entry 411: applies from this date
CLP classification “Eye Irrit. 2” applicable at the latest from this date (Regulation (EU) 2018/669)
Identity
- CosIng identifier
- 84556
- CAS (according to CosIng)
- 110-97-4
- EC (according to CosIng)
- 203-820-9
- Declared functions
- Buffering
CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
1,1'-iminodipropan-2-ol; di-isopropanolamine
Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification
- Hazard classes
- Eye irritation, category 2 (Eye Irrit. 2)
- Hazard statements
- H319
Annex VI, entry 603-083-00-7, linked by CAS 110-97-4. Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
Entry introduced or replaced by Regulation (EU) 2018/669, applicable at the latest from 1 December 2019.
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Prohibited in cosmetics | not cited |
| United Kingdom | Prohibited in cosmetics | not cited |
| Switzerland | EU Regulation applies | not cited |
| United States (federal) | No federal rule recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | No entry in the lists recorded | not cited |
| China | Not on the prohibited lists recorded (lists of allowed substances are not recorded) | not cited |
| Australia | No entry in the lists recorded | not cited |
| Brazil | Prohibited | not cited |
United Kingdom (Great Britain)
- Prohibited in cosmetics (Annex II)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
Brazil
- Prohibited: Alquilaminas e alcanolaminas secundárias e seus sais
RDC 529/2021, Anexo (prohibited substances), entry 411, page 15;16.
Conditions, source text, in Portuguese
N° UE: 411
Brazil, ANVISA resolutions RDC 529/2021, 528/2021, 600/2022 and 628/2022, retrieved 22 October 2026.
Source: ANVISA. Text of the adopted draft resolutions, as the Official Journal could not be accessed; the 2021 lists of prohibited substances and preservatives were compared with the copy of the published text distributed by the State of Paraná, the 2022 lists of UV filters and colorants were not.
Recorded cosmetics that contain it
1 recorded product list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.