DIISOPROPYLAMINE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 8788
- Prohibited in cosmetics (Annex II)
DIISOPROPYLAMINE: Prohibited in cosmetics (Annex II, entry 411), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 23 October 2026.
Who it concerns
This ingredient is prohibited in cosmetics in the European Union: what follows describes its hazards, not a permitted use.
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.
Babies and children
Prohibited in cosmetics in the European Union for everyone, whatever the age or situation: no specific condition is therefore needed for this group.
Skin, eyes and allergies
For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
For information Classified under the CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). Regulation: skin corrosion, category 1B (Skin Corr. 1B). This classification describes the pure substance; in a finished product it is far more diluted.
Environment
No harmonised classification as hazardous to the aquatic environment, and it is not on ECHAEuropean Chemicals Agency.'s Candidate List as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
In plain words
What it is used for
Functions declared by manufacturers:
Buffering: stabilises the pH of cosmetics.
Functions declared in the CosIngThe European Commission's database of cosmetic ingredients. inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Definitions of functions (decision repealed on 8 May 2020, cited for information). Decision 2006/257/EC, inventory of cosmetic ingredients (definitions of functions), retrieved 22 October 2026.
What the rules say
It is prohibited to use it in a cosmetic product sold in the European Union, whatever the dose. If it appears on the ingredient list of a recent product, this needs checking: the record may be old or wrong, or the product intended for another market.
CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.
Origin and odour
No natural occurrence recorded in Wikidata (LOTUS database); this does not prove that the ingredient is synthetic.
Basis: one CosIng CAS, with no natural occurrence recorded in this database.
Wikidata: names of substances in six languages and taxa in which they occur (largely from the LOTUS database), retrieved 23 October 2026.
Other names: Diisopropylamin (German), Diisopropilamina (Spanish), di-isopropilamina (Portuguese).
Wikidata: names of substances in six languages and taxa in which they occur (largely from the LOTUS database), retrieved 23 October 2026.
Present in 0.0% of recorded cosmetics (0 out of 21 443).
Open Beauty Facts, export of cosmetic products, retrieved 23 October 2026.
Data “Open Beauty Facts and its contributors”, licensed under ODbL 1.0 (opendatacommons.org/licenses/odbl/1-0); derived table distributed under the same licence.
The text of the annexes
Prohibited in cosmetics
CosIng links the name DIISOPROPYLAMINE to this Annex II entry.
- Entry
- Annex II, No 411
- Substance
- Secondary alkyl- and alkanolamines and their salts
- CAS
- 111-42-2 / 110-97-4
- EC
- 203-868-0 / 203-820-9
Regulation (EC) No 1223/2009, Annex II, entry 411. CosIng, Annex II of Regulation (EC) No 1223/2009 (prohibited substances), retrieved 23 October 2026, source updated 13 October 2026.
Entry from Regulation (EC) No 1223/2009, adopted on 30 November 2009.
SCCSEU Scientific Committee on Consumer Safety: it assesses cosmetic ingredients. opinions cited: Opinion concerning Dialkyl- and Dialkanolamines and their salts in cosmetic products; Opinion concerning banning of Dialkanolamines which are still in the inventory.
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex II, entry 411: introduced or replaced by Regulation (EC) No 1223/2009
Annex II, entry 411: applies from this date
CLP classification “Flam. Liq. 2” applicable at the latest from this date (Regulation (EU) 2018/669)
Identity
CosIng inventory. CosIng, inventory of cosmetic ingredients (INCI names, CAS, EC, functions), retrieved 21 October 2026.
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
diisopropylamine
Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification
- Hazard classes
- Flammable liquid, category 2 (Flam. Liq. 2)
Acute toxicity, category 4 (Acute Tox. 4)
Skin corrosion, category 1B (Skin Corr. 1B) - Hazard statements
- H225 H332 H302 H314
Annex VI, entry 612-129-00-5, linked by CAS 108-18-9. Regulation (EC) No 1272/2008 (CLP), consolidated version, Annex VI table 3, retrieved 21 October 2026.
Entry introduced or replaced by Regulation (EU) 2018/669, applicable at the latest from 1 December 2019.
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Prohibited in cosmetics | not cited |
| United Kingdom | Prohibited in cosmetics | not cited |
| Switzerland | EU Regulation applies | not cited |
| United States (federal) | No federal rule recorded | not cited |
| Canada | Prohibited | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | No entry in the lists recorded | not cited |
| China | Not on the prohibited lists recorded (lists of allowed substances are not recorded) | not cited |
| Australia | No entry in the lists recorded | not cited |
| ASEAN | No entry in the lists recorded | not cited |
| Taiwan | No entry in the lists recorded | not cited |
| Brazil | No entry in the lists recorded | not cited |
United Kingdom (Great Britain)
- Prohibited in cosmetics (Annex II)
Same entries as in the European Union. Their maximum concentrations are compared in the “Comparison between countries” table; other conditions (product types, warnings) may differ.
Annexes II to VI in force. United Kingdom, Annexes II to VI of Regulation (EC) No 1223/2009 as retained and amended, retrieved 21 October 2026.
Contains public sector information licensed under the Open Government Licence v3.0.
Northern Ireland applies EU law.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
Switzerland, FDHA Ordinance on Cosmetic Products (OCos, SR 817.023.31), consolidated version, retrieved 22 October 2026.
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
United States, 21 CFR part 700 and section 250.250 (FDA rules on cosmetic ingredients), eCFR, retrieved 21 October 2026.
The eCFR is not an official legal edition of the Code of Federal Regulations.
Canada
- Prohibited: Alkyl- et alcanolamines secondaires et leurs sels (Secondary alkyl- and alkanolamines and their salts)
Hotlist, prohibited ingredients. Synonyms and related compounds: Diethanolamine (DEA); Diisopropanolamine (DIPA); DEA-Cetyl Phosphate; DEA-Oleth-3 Phosphate; DEA-Oleth-10 Phosphate; Spermidine; Spermidine HCl; Diisopropylamine
Canada, Health Canada Cosmetic Ingredient Hotlist (prohibited and restricted ingredients), retrieved 24 October 2026.
Source: Health Canada, Cosmetic Ingredient Hotlist (canada.ca, French and English pages); table extracted and formatted by the publisher of this site, not the official version, with no endorsement by Health Canada.
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 23 October 2026.