ISOBUTANE
Official label name (INCI name, EU glossary of cosmetic ingredient names), No 13669
- Prohibited above an impurity threshold (Annex II)
ISOBUTANE: Prohibited above an impurity threshold (Annex II, entry 464), under Regulation (EC) No 1223/2009.
In plain words
What it is used for
Functions declared by manufacturers:
Propellant: generates pressure in an aerosol pack, expelling contents when the valve is opened. Some liquefied propellants can act as solvents.
What the rules say
Prohibited only if the substance contains at least 0.1% (w/w) butadiene. This content does not appear on an ingredient list.
Hazard and risk
A specific form or grade of this substance (the one described in the title of the CLP entry) is classified as carcinogenic, category 1A (known effect in humans) and mutagenic (may damage DNA), category 1B (presumed effect, established mainly from animal studies). Its other forms fall under another entry.
This classification describes what the substance can cause (a hazard), not what happens when using a product (a risk): the risk depends on the dose, the form and the route of exposure (skin, inhalation, ingestion).
The text of the annexes
Prohibited above an impurity threshold
CosIng links the name ISOBUTANE to this entry. The cases of prohibition are explained above, in “In plain words”; the official title is given below.
- Entry
- Annex II, No 464
- Substance
- Isobutane, if it contains = >0,1% w/w Butadiene
- CAS
- 75-28-5
- EC
- 200-857-2
- CMR
- Carcinogenic Cat. 1A(),Mutagenic Cat. 1B()
Dates in the act (10)
- Entry into force on 11 January 2010
- Application from 1 December 2010
It shall apply from 11 July 2013, with the exception of: — Article 15(1) and (2) which shall apply from 1 December 2010, as well as Articles 14, 31 and 32 to the extent that they are necessary to apply Article 15(1) and (2); and — Article 16(3) second subparagraph, which shall apply from 11 January 2013.
- Entry into force on 1 December 2010
- Condition applicable from 11 January 2012
As from 11 January 2012, by way of derogation from Directive 76/768/EEC, notification carried out in accordance with Article 13 of this Regulation shall be considered to comply with Article 7(3) and Article 7a(4) of that Directive
- Application from 11 January 2013
July 2013, with the exception of: — Article 15(1) and (2) which shall apply from 1 December 2010, as well as Articles 14, 31 and 32 to the extent that they are necessary to apply Article 15(1) and (2); and — Article 16(3) second subparagraph, which shall apply from 11 January 2013.
- Entry into force on 11 January 2013
- Application from 11 July 2013
It shall apply from 11 July 2013, with the exception of: — Article 15(1) and (2) which shall apply from 1 December 2010, as well as Articles 14, 31 and 32 to the extent that they are necessary to apply Article 15(1) and (2); and — Article 16(3) second subparagraph, which shall appl
- Entry into force on 11 July 2013
- Placing on the market before 11 July 2013
Article 39 Transitional provisions By way of derogation from Directive 76/768/EEC, cosmetic products which comply with this Regulation may be placed on the market before 11 July 2013.
- Placing on the market from 11 July 2013
As from 11 July 2013, a distributor who makes available in a Member State a cosmetic product already placed on the market in another Member State and translates, on his own initiative, any element of the labelling of that product in order to comply with national law, shall submit, by electronic means, the following info
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Identity
- CosIng identifier
- 76816
- CAS (according to CosIng)
- 75-28-5
- EC (according to CosIng)
- 200-857-2
- Declared functions
- Propellant
- Wikidata
- Q407225
- PubChem
- 6360
- ECHA InfoCard
- 100.000.780
- InChIKey
- NNPPMTNAJDCUHE-UHFFFAOYSA-N
Classified hazard (CLP Regulation)
A classification describes an intrinsic hazard, not a risk: the risk depends on the dose, the form and the exposure.
butane; [1] and isobutane [2]
No harmonised CMR classification
- Hazard classes
- Flam. Gas 1
Press. Gas - Hazard statements
- H220
- CLP notes
- C U
butane (containing ≥ 0,1 % butadiene (203-450-8)); [1] isobutane (containing ≥ 0,1 % butadiene (203-450-8)) [2]
CMR Carc. 1A ; Muta. 1B
- Hazard classes
- Flam. Gas 1
Press. Gas
Carc. 1A
Muta. 1B - Hazard statements
- H220 H350 H340
- CLP notes
- C S U
The CMR classification covers only a specific form or grade of the substance (particle size or impurity content stated in the entry's title); another CLP entry covers its other forms.
Elsewhere in the world
Information on other jurisdictions. What is covered, and what is not yet.
United Kingdom (Great Britain)
- Prohibited above an impurity threshold (Annex II)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
China
- Prohibited: 丁二烯含量大于或等于 0.1%（w/w）的异丁烷 (Isobutane （CAS No. 75-28-5）, if it contains ≥0.1%（w/w） butadiene)
表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 848, page 附件2 (.doc) table row 848 ; TID reprint p.33.
Brazil
- Prohibited: Isobutano, se contiver ≥ 0,1 % (m/m) de butadieno
RDC 529/2021, Anexo (prohibited substances), entry 464, page 17. Conditions (source text, in Portuguese): N° UE: 464
Recorded cosmetics that contain it
606 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (page in French).
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.