OXYQUINOLINE SULFATE
Official label name (INCIInternational name of cosmetic ingredients: the one printed on the pack. name, EU glossary of cosmetic ingredient names), No 18549
- Prohibited, with exceptions (Annex II)
- Allowed with restrictions (Annex III)
OXYQUINOLINE SULFATE: Prohibited, with exceptions (Annex II, entry 395); allowed with restrictions, with limits depending on the product type (Annex III, entry 51), under Regulation (EC) No 1223/2009. Annexes of the Regulation consulted on 21 October 2026.
Who it concerns
What official classifications and rules say for each group. A classification describes the hazard of the pure substance, not the risk of a product that contains it, which depends on the dose and the exposure.
Prohibition or serious classificationThe text prohibits the substance for this use, or ranks it among the most serious hazards (known or presumed carcinogenic, mutagenic or reprotoxic, identified endocrine disruptor).Worth watchingThe text sets a condition or flags a hazard worth knowing: allergen, suspected effect, condition for children, hazard to the aquatic environment.For informationOfficial information with no condition on a finished product: warning to read, irritation of the pure substance.
Pregnancy and breastfeeding
No classification harmonised by the European Union covers reproduction, the unborn child or breastfeeding for this substance. This does not mean it has been judged to have no effect during pregnancy.
Babies and children
The Cosmetics Regulation sets no age-related condition for this ingredient.
Skin, eyes and allergies
No official classification for sensitisation, irritation or eye damage, and no obligation to label it as an allergen.
Environment
No official classification as hazardous to the aquatic environment and no assessment as an endocrine disruptor for the environment.
Read on the label
The Cosmetics Regulation requires no warning to be printed for this ingredient.
In plain words
What it is used for
Functions declared by manufacturers:
Antimicrobial: helps control the growth of micro-organisms on the skin.
Chelating: reacts and forms complexes with metal ions which could affect the stability and/or appearance of cosmetics.
What the rules say
Prohibited, with the exceptions set out in the official title: "Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III".
Allowed, with restrictions: Annex III sets a maximum concentration and the product types allowed. Ingredient lists do not give quantities, so the concentration cannot be checked on the label.
The text of the annexes
Prohibited, with exceptions
CosIng links the name OXYQUINOLINE SULFATE to this entry. The cases of prohibition are explained above, in “In plain words”; the official title is given below.
- Entry
- Annex II, No 395
- Substance
- Hydroxy-8-quinoline and its sulphate bis(8-hydroxyquinolinium) sulphate, except for the uses of the sulphate provided for in entry 51 of Annex III
- CAS
- 148-24-3 [1]; 134-31-6 [2]
- EC
- 205-711-1 [1]; 205-137-1 [2]
Dates in the act (5)
- Application from 11 June 2019
Points (1)(a) and (2)(b) of Annex II shall apply from 11 June 2019.
- Entry into force on 11 June 2019
- Entry into force on 18 December 2019
- Application from 1 May 2020
Article 1 shall apply from 1 May 2020.
- Entry into force on 1 May 2020
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
Allowed with restrictions
| Product type | Maximum concentration |
|---|---|
| (a) Stabilizer for hydrogen peroxide in rinse-off hair products | (0.3% as base) |
| (b) Stabilizer for hydrogen peroxide in leave-on hair products | (0.03% as base) |
- Entry
- Annex III, No 51
- Substance
- bis(8-hydroxyquinolinium) sulphate
- Glossary names
- OXYQUINOLINE SULFATE
- CAS
- 134-31-6
- EC
- 205-137-1
Dates in the act (5)
- Application from 11 June 2019
Points (1)(a) and (2)(b) of Annex II shall apply from 11 June 2019.
- Entry into force on 11 June 2019
- Entry into force on 18 December 2019
- Application from 1 May 2020
Article 1 shall apply from 1 May 2020.
- Entry into force on 1 May 2020
Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.
What has changed, and what will change
Dates of the texts that cover this ingredient. A text date may cover several substances: the details of each entry are below.
Annex II, entry 395: introduced or replaced by Regulation (EU) 2019/1966
Annex III, entry 51: introduced or replaced by Regulation (EU) 2019/1966
CLPEU regulation that classifies chemicals by their hazards (EC No 1272/2008). classification “Acute Tox. 4*” applicable at the latest from this date (Regulation (EU) 2018/669)
Annex II, entry 395: applies from this date
Annex III, entry 51: applies from this date
Identity
- CosIng identifier
- 35775
- CAS (according to CosIng)
- 134-31-6
- EC (according to CosIng)
- 205-137-1
- Declared functions
- Antimicrobial, Chelating
- Wikidata
- Q27263388
- ECHAEuropean Chemicals Agency. InfoCard
- 100.004.671
- InChIKey
- YYVFXSYQSOZCOQ-UHFFFAOYSA-N
Classified hazard (CLP Regulation)
The harmonised classification is the one set by the European Union for the whole Union. H codes refer to the hazard statements of Annex III of Regulation (EC) No 1272/2008.
bis(8-hydroxyquinolinium) sulphate
Neither carcinogenic, mutagenic nor toxic for reproduction under the harmonised classification
- Hazard classes
- Acute toxicity, category 4 (Acute Tox. 4)
- Hazard statements
- H302
Elsewhere in the world
Information on other jurisdictions, with no effect on sale in France. What is covered, and what is not yet.
Comparison between countries
Most restrictive status in each country, and the maximum concentration cited. The details and the source of each rule follow.
| Country | Rule | Maximum concentration cited |
|---|---|---|
| European Union | Prohibited, with exceptions | 0.03 to 0.3% |
| United Kingdom | Prohibited, with exceptions | 0.03 to 0.3% |
| Switzerland | EU Regulation applies | 0.03 to 0.3% |
| United States (federal) | No federal rule recorded | not cited |
| Japan | No entry in the lists recorded | not cited |
| South Korea | Prohibited differs from the EU | not cited |
| China | Prohibited differs from the EU | not cited |
| Australia | No entry in the lists recorded | not cited |
| Brazil | Prohibited differs from the EU | not cited |
United Kingdom (Great Britain)
- Prohibited, with exceptions (Annex II)
- Allowed with restrictions (Annex III)
Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.
Switzerland
Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).
United States, federal rules
None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.
South Korea
- Prohibited: 옥시퀴놀린(히드록시-8-퀴놀린 또는 퀴놀린-8-올) 및 그 황산염 (OXYQUINOLINE SULFATE)
별표 1 (prohibited substances), entry 635, page 34.
Conditions, source text, in Korean
화학물질명: 옥시퀴놀린(히드록시-8-퀴놀린 또는 퀴놀린-8-올) (CAS No. 148-24-3) | 화학물질명: 옥시퀴놀린 설페이트 (CAS No. 134-31-6)
China
- Prohibited: 8-羟基喹啉及其硫酸盐（化妆品限用组分中的8-羟基喹啉硫酸盐除外） (Hydroxy-8-quinoline （CAS No. 148-24-3） and its sulfate （CAS No. 134-31-6）, except for the uses of the sulphate provided in restricted substances in cosmetics products)
表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 834, page 附件2 (.doc) table row 834 ; TID reprint p.33.
Brazil
- Prohibited: Hidroxi-8-quinolina e seu sulfato, exceto os mencionados em outras listas de substâncias
RDC 529/2021, Anexo (prohibited substances), entry 395, page 15.
Conditions, source text, in Portuguese
N° UE: 395
Recorded cosmetics that contain it
6 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (in French).
Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.