Compoatlas

POLYAMINOPROPYL BIGUANIDE

Official label name (INCI name, EU glossary of cosmetic ingredient names), No 21603

POLYAMINOPROPYL BIGUANIDE: Preservative allowed under conditions, maximum 0.1% in the ready-for-use preparation (Annex V, entry 28), under Regulation (EC) No 1223/2009.

In plain words

What it is used for

Functions declared by manufacturers:

Preservative: inhibits primarily the development of micro-organisms in cosmetics.

What the rules say

An ingredient can be used as a preservative only if it appears on the list of Annex V. <function plain_language.<locals>.name at 0x7f7804e05d00> is on it with a maximum concentration.

The text of the annexes

Preservative allowed under conditions

Entry
Annex V, No 28
Substance
Polyhexamethylene biguanide hydrochloride
Glossary names
POLYAMINOPROPYL BIGUANIDE
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
EC
608-723-9 [1]/ 608-042-7 [2]
Maximum concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation
CMR
Carcinogenic Cat. 2()
Dates in the act (1)
  • Entry into force on 12 June 2019

Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.

Identity

CosIng identifier
36692
CAS (according to CosIng)
133029-32-0, 27083-27-8, 28757-47-3, 32289-58-0
EC (according to CosIng)
608-042-7, 608-723-9, 923-111-4
Declared functions
Preservative

CosIng cites 4 CAS numbers for this name: it covers several substances.

Elsewhere in the world

Information on other jurisdictions. What is covered, and what is not yet.

United Kingdom (Great Britain)

  • Preservative allowed under conditions (Annex V)

Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

Japan

  • Allowed under conditions: ポリアミノプロピルビグアナイド (Polyaminopropyl biguanide)

    Annex 3-2 (allowed preservatives), entry 28, page 9. Conditions (source text, in Japanese): [sous-liste] 2　化粧品の種類により配合の制限がある成分(注1) | 100g中の最大配合量（ｇ） / 粘膜に使用されることがない化粧品のうち洗い流すもの: 0.1 | 100g中の最大配合量（ｇ） / 粘膜に使用されることがない化粧品のうち洗い流さないもの: 0.1 | 100g中の最大配合量（ｇ） / 粘膜に使用されることがある化粧品: 0.1 | (注1)　空欄は、配合してはならないことを示し、○印は、配合の上限がないことを示す。

South Korea

  • Restricted: 폴리(1-헥사메칠렌바이구아니드)에이치씨엘 (POLYAMINOPROPYL BIGUANIDE)

    별표 2, 보존제 성분 (preservatives), entry 53, page 11. Limit: 0.05%. Conditions (source text, in Korean): 비고: 에어로졸(스프레 이에 한함) 제품에는 사용금지 | 화학물질명: 폴리아미노프로필바이구아나이드 (CAS No. 32289-58-0)

Brazil

  • Allowed under conditions: Cloridrato de polihexametileno biguanida (POLYAMINOPROPYL BIGUANIDE)

    RDC 528/2021, Anexo (allowed preservatives), entry 25, page 4. Limit: 0,1%. Conditions (source text, in Portuguese): LIMITAÇÕES: Proibido em produtos cuja aplicação possa conduzir à exposição pela via de inalação.

Recorded cosmetics that contain it

40 recorded products list it, according to Open Beauty Facts contributors. Records are dated: the formula may have changed. See the list (page in French).

Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.