Compoatlas

THIRAM

Official label name (INCI name, EU glossary of cosmetic ingredient names), No 28773

THIRAM: Prohibited in cosmetics (Annex II, entry 162), under Regulation (EC) No 1223/2009.

In plain words

What it is used for

Functions declared by manufacturers:

Antimicrobial: helps control the growth of micro-organisms on the skin.

What the rules say

It is prohibited to use it in a cosmetic product sold in the European Union, whatever the dose. If it appears on the ingredient list of a recent product, this needs checking: the record may be old or wrong, or the product intended for another market.

The text of the annexes

Prohibited in cosmetics

CosIng links the name THIRAM to this Annex II entry.

Entry
Annex II, No 162
Substance
Disulfiram (INN); thiram (ISO) (INN)
CAS
97-77-8 / 137-26-8
EC
202-607-8 / 205-286-2
Dates in the act (10)
  • Entry into force on 11 January 2010
  • Application from 1 December 2010
    It shall apply from 11 July 2013, with the exception of: — Article 15(1) and (2) which shall apply from 1 December 2010, as well as Articles 14, 31 and 32 to the extent that they are necessary to apply Article 15(1) and (2); and — Article 16(3) second subparagraph, which shall apply from 11 January 2013.
  • Entry into force on 1 December 2010
  • Condition applicable from 11 January 2012
    As from 11 January 2012, by way of derogation from Directive 76/768/EEC, notification carried out in accordance with Article 13 of this Regulation shall be considered to comply with Article 7(3) and Article 7a(4) of that Directive
  • Application from 11 January 2013
    July 2013, with the exception of: — Article 15(1) and (2) which shall apply from 1 December 2010, as well as Articles 14, 31 and 32 to the extent that they are necessary to apply Article 15(1) and (2); and — Article 16(3) second subparagraph, which shall apply from 11 January 2013.
  • Entry into force on 11 January 2013
  • Application from 11 July 2013
    It shall apply from 11 July 2013, with the exception of: — Article 15(1) and (2) which shall apply from 1 December 2010, as well as Articles 14, 31 and 32 to the extent that they are necessary to apply Article 15(1) and (2); and — Article 16(3) second subparagraph, which shall appl
  • Entry into force on 11 July 2013
  • Placing on the market before 11 July 2013
    Article 39 Transitional provisions By way of derogation from Directive 76/768/EEC, cosmetic products which comply with this Regulation may be placed on the market before 11 July 2013.
  • Placing on the market from 11 July 2013
    As from 11 July 2013, a distributor who makes available in a Member State a cosmetic product already placed on the market in another Member State and translates, on his own initiative, any element of the labelling of that product in order to comply with national law, shall submit, by electronic means, the following info

Excerpts from the English text published in the Official Journal. A date may concern only some substances of the act: the excerpt says so.

Identity

CosIng identifier
84655
CAS (according to CosIng)
137-26-8
EC (according to CosIng)
205-286-2
Declared functions
Antimicrobial

Classified hazard (CLP Regulation)

A classification describes an intrinsic hazard, not a risk: the risk depends on the dose, the form and the exposure.

thiram (ISO); tetramethylthiuram disulphide

No harmonised CMR classification

Hazard classes
Acute Tox. 4 *
Acute Tox. 4 *
STOT RE 2 *
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
Aquatic Acute 1
Aquatic Chronic 1
Hazard statements
H332 H302 H373 ** H319 H315 H317 H400 H410

Elsewhere in the world

Information on other jurisdictions. What is covered, and what is not yet.

United Kingdom (Great Britain)

  • Prohibited in cosmetics (Annex II)

Same entries as in the European Union. Conditions (concentrations, warnings) may differ: they are not compared here.

Switzerland

Regulation (EC) No 1223/2009 applies in Switzerland (Article 54 of the Ordinance on Foodstuffs and Utility Articles).

United States, federal rules

None of the integrated sections of the federal code (21 CFR 700.11 to 700.27 and 250.250) targets this name. The FDA does not publish a list of allowed ingredients.

Japan

  • Restricted by product type: チラム (Thiram)

    Annex 2-2 (restricted substances), entry 2, page 4. Limit: 0.50g per 100 g of product. Conditions (source text, in Japanese): [sous-liste] 2　化粧品の種類又は使用目的により配合の制限がある成分 | [en-tête de groupe] 石けん、シャンプー等の直ちに洗い流す化粧品 | 100ｇ中の最大配合量: 0.50ｇ

  • Restricted by product type: チラム (Thiram)

    Annex 2-2 (restricted substances), entry 4, page 4. Limit: 0.30g per 100 g of product. Conditions (source text, in Japanese): [sous-liste] 2　化粧品の種類又は使用目的により配合の制限がある成分 | [en-tête de groupe] 石けん、シャンプー等の直ちに洗い流す化粧品以外の化粧品 | 100ｇ中の最大配合量: 0.30ｇ

South Korea

  • Prohibited: 치람 (THIRAM)

    별표 1 (prohibited substances), entry 683, page 36.

  • Prohibited: 티우람디설파이드 (THIRAM)

    별표 1 (prohibited substances), entry 884, page 45.

China

  • Prohibited: 双硫仑; 塞仑 (Disulfiram （INN） （CAS No 97-77-8）; thiram （INN） （CAS No. 137-26-8）)

    表1 化妆品禁用原料目录 (prohibited substances, 2021年第74号), entry 582, page 附件2 (.doc) table row 582 ; TID reprint p.23.

Brazil

  • Prohibited: Dissulfiram*; Tiram* (ISO)

    RDC 529/2021, Anexo (prohibited substances), entry 162, page 7. Conditions (source text, in Portuguese): N° UE: 162

  • Prohibited: Dissulfetos de Tiurão

    RDC 529/2021, Anexo (prohibited substances), entry 354, page 13. Conditions (source text, in Portuguese): N° UE: 354

Glossary: Commission Implementing Decision (EU) 2025/1175. Page updated on 21 October 2026.